SCHEMBL21186282

SCHEMBL21186282

Nc1nc2ccc(Oc3ccccc3)nc2s1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.55
RAB9A P51151 2/20 0.55
HTT P42858 2/20 0.55
MAPT P10636 2/20 0.55
TP53 P04637 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
MAP4K4 O95819 3/20 0.50
HCK P08631 2/20 0.50
BTK Q06187 2/20 0.50
BCAT2 O15382 1/20 0.45
PIK3CA P42336 1/20 0.41
PI4KA P42356 1/20 0.41
PI4KB Q9UBF8 1/20 0.41
CYP3A4 P08684 2/20 0.40
ALDH1A1 P00352 2/20 0.40
TDP1 Q9NUW8 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
NUDT1 P36639 1/20 0.38
CYP1A2 P05177 1/20 0.37
CYP2C19 P33261 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21186292 0.84 MEN1 (0.50) NPC1RAB9AHTTMAPTTP53
SCHEMBL30526790 0.84 MEN1 (0.45) NPC1RAB9AHTTMAPTTP53
SCHEMBL30526748 0.81 MAP4K4 (0.55) NPC1RAB9AHTTMAPTTP53
SCHEMBL19454640 0.81 RAB9A (0.40) NPC1RAB9AHTTMAPTTP53
SCHEMBL23720084 0.79 MAP4K4 (0.54) NPC1RAB9AHTTMAPTTP53
SCHEMBL23720038 0.79 CYP3A4 (0.43) NPC1RAB9AHTTMAPTTP53
SCHEMBL19454539 0.79 RAB9A (0.38) NPC1RAB9AHTTMAPTTP53
SCHEMBL29504602 0.79 ALDH1A1 (0.40) NPC1RAB9AHTTMAPTTP53
SCHEMBL19434919 0.79 ALDH1A1 (0.40) NPC1RAB9AHTTMAPTTP53
SCHEMBL2861313 0.79 KDR (0.49) NPC1RAB9AHTTMAPTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4585599-A1 NITROGEN-CONTAINING FUSED RING COMPOUND, INTERMEDIATE THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF Hangzhou Synrx Therapeutics Biomedical Technology Co., Ltd. (CN) 2025-07-16 EP disclosed
CN-117946138-A And ring nitrogen-containing compound, intermediate thereof, preparation method and application 杭州圣域生物医药科技有限公司 2024-04-30 CN disclosed
WO-2019141980-A1 AGRICULTURAL CHEMICALS GLOBACHEM NV (BE) 2019-07-25 WO disclosed