Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.47 |
| ▸ | TNF | P01375 | 2/20 | 0.44 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2120001 | 0.89 | TP53 (0.49) | PIK3CDPIK3CGTNFSLC40A1ALDH1A1 | |
| SCHEMBL2118402 | 0.89 | TNF (0.44) | PIK3CDPIK3CGTNFSLC40A1PIK3CA | |
| SCHEMBL2119785 | 0.82 | ACLY (0.59) | PIK3CAMTORHSD11B1ACLY | |
| SCHEMBL2120193 | 0.81 | ACLY (0.46) | ALDH1A1POLBCYP3A4SMN1; SMN2TDP1 | |
| SCHEMBL2120031 | 0.81 | ACLY (0.44) | ALDH1A1POLBCYP3A4SMN1; SMN2TDP1 | |
| SCHEMBL2120602 | 0.81 | HSD11B1 (0.45) | PIK3CDPIK3CGPIK3CAMTORALDH1A1 | |
| SCHEMBL2119726 | 0.81 | KDM1A (0.48) | PIK3CDPIK3CAMTORPOLBSMN1; SMN2 | |
| SCHEMBL2118252 | 0.79 | TUBB4A (0.54) | ALDH1A1CYP3A4SMN1; SMN2TDP1HSD11B1 | |
| SCHEMBL2122742 | 0.79 | ACLY (0.42) | ALDH1A1POLBCYP3A4SMN1; SMN2TDP1 | |
| SCHEMBL2118244 | 0.78 | ABCB1 (0.51) | PIK3CDPIK3CGPIK3CAMTORPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120095024-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE | ELARA PHARMACEUTICALS GMBH (DE) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095024-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE | HIF1AN, HIF1A, EGLN2 | PIK3CD 1602/4885PIK3CG 2889/4885TNF 135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.