Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 4/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | GPR6 | P46095 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 2/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21187293 | 0.91 | PIK3CD (0.37) | PIK3C3SYKPDE10ATBK1IKBKE | |
| SCHEMBL21178651 | 0.91 | PIK3CD (0.37) | PIK3C3SYKPDE10ATBK1IKBKE | |
| SCHEMBL30823294 | 0.91 | PIK3CD (0.37) | PIK3C3SYKPDE10ATBK1IKBKE | |
| SCHEMBL21187365 | 0.91 | PIK3C3 (0.38) | PIK3C3SYKPDE10ATBK1IKBKE | |
| SCHEMBL30823273 | 0.91 | PIK3C3 (0.38) | PIK3C3SYKPDE10ATBK1IKBKE | |
| SCHEMBL21177873 | 0.91 | PIK3C3 (0.38) | PIK3C3SYKPDE10ATBK1IKBKE | |
| SCHEMBL21177867 | 0.90 | TBK1 (0.41) | TBK1IKBKEIRAK4JAK2JAK1 | |
| SCHEMBL30823317 | 0.90 | TBK1 (0.41) | TBK1IKBKEIRAK4JAK2JAK1 | |
| SCHEMBL22651978 | 0.90 | TBK1 (0.41) | TBK1IKBKEIRAK4JAK2JAK1 | |
| SCHEMBL22635848 | 0.87 | IRAK4 (0.38) | PIK3C3SYKPDE10ATBK1IKBKE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019143678-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-07-25 | — | — | WO | disclosed |