Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | MPI | P34949 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26431777 | 0.85 | ALDH1A1 (0.34) | ALDH1A1MAPT | |
| SCHEMBL30288080 | 0.76 | UHRF1 (0.35) | KDM4EMEN1ALDH1A1TP53GAA | |
| SCHEMBL24011589 | 0.76 | UHRF1 (0.35) | KDM4EMEN1ALDH1A1TP53GAA | |
| SCHEMBL31011770 | 0.72 | CHRNB4 (0.33) | — | |
| SCHEMBL31011768 | 0.72 | CHRNB4 (0.33) | — | |
| SCHEMBL1686017 | 0.71 | UHRF1 (0.40) | KDM4EMEN1ALDH1A1TP53GAA | |
| SCHEMBL21187390 | 0.70 | MAPT (0.35) | KDM4EMEN1ALDH1A1MAPTALOX15 | |
| SCHEMBL31127815 | 0.70 | CHRNB4 (0.33) | — | |
| SCHEMBL23647865 | 0.70 | CCNB2 (0.31) | MAPT | |
| SCHEMBL15523824 | 0.69 | PARP10 (0.43) | KDM4EMEN1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019143678-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-07-25 | — | — | WO | disclosed |