Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 7/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 7/20 | 0.41 |
| ▸ | TAS1R2 | Q8TE23 | 5/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HTR5A | P47898 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30644700 | 0.94 | DRD2 (0.42) | DRD2DRD4DRD3HTR5ATSHR | |
| SCHEMBL26705413 | 0.94 | DRD2 (0.42) | DRD2DRD4DRD3HTR5ATSHR | |
| SCHEMBL19973522 | 0.85 | TAS1R3 (0.40) | TAS1R3TAS1R1TAS1R2KMT2AMEN1 | |
| SCHEMBL19973512 | 0.85 | TAS1R3 (0.40) | TAS1R3TAS1R1TAS1R2KMT2AMEN1 | |
| SCHEMBL19973513 | 0.85 | TAS1R3 (0.40) | TAS1R3TAS1R1TAS1R2KMT2AMEN1 | |
| SCHEMBL19508304 | 0.82 | ALDH1A1 (0.41) | DRD2DRD4DRD3HTR5ATSHR | |
| SCHEMBL21300445 | 0.82 | ALDH1A1 (0.41) | DRD2DRD4DRD3HTR5ATSHR | |
| SCHEMBL21189240 | 0.80 | TSHR (0.37) | TSHRALDH1A1HSD17B10TDP1L3MBTL1 | |
| SCHEMBL21189239 | 0.80 | TSHR (0.37) | TSHRALDH1A1HSD17B10TDP1L3MBTL1 | |
| SCHEMBL3583095 | 0.79 | TAS1R3 (0.38) | TAS1R3TAS1R1TAS1R2ALDH1A1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11001564-B2 | Substituted chromane-8-carboxamide compounds and analogues thereof, and methods using same | ARBUTUS BIOPHARMA CORPORATION (CA) | 2021-05-11 | — | — | US | disclosed |
| US-20190225593-A1 | SUBSTITUTED CHROMANE-8-CARBOXAMIDE COMPOUNDS AND ANALOGUES THEREOF, AND METHODS USING SAME | ARBUTUS BIOPHARMA CORP (CA) | 2019-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190225593-A1 | SUBSTITUTED CHROMANE-8-CARBOXAMIDE COMPOUNDS AND ANALOGUES THEREOF, AND METHODS USING SAME | CBX8, HAVCR2, HCCS | TAS1R3 3760/4885TAS1R1 3802/4885TAS1R2 3995/4885 |
| US-11001564-B2 | Substituted chromane-8-carboxamide compounds and analogues thereof, and methods using same | CBX8, HAVCR2, HCCS | TAS1R3 3760/4885TAS1R1 3802/4885TAS1R2 3995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.