Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 2/20 | 0.58 |
| ▸ | SCD | O00767 | 1/20 | 0.58 |
| ▸ | APP | P05067 | 1/20 | 0.57 |
| ▸ | MMP2 | P08253 | 1/20 | 0.57 |
| ▸ | MMP9 | P14780 | 1/20 | 0.57 |
| ▸ | MMP8 | P22894 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687502 | 0.81 | MAPT (0.68) | MMP13SCDAPPMMP2MMP9 | |
| SCHEMBL687503 | 0.81 | MAPT (0.68) | MMP13SCDAPPMMP2MMP9 | |
| SCHEMBL12545717 | 0.81 | RAB9A (0.55) | ALDH1A1ALOX15MAPTKMT2AMEN1 | |
| SCHEMBL686788 | 0.80 | THRB (0.52) | MMP13SCDAPPMMP2MMP9 | |
| SCHEMBL686787 | 0.80 | THRB (0.52) | MMP13SCDAPPMMP2MMP9 | |
| SCHEMBL2119633 | 0.79 | NPC1 (0.52) | APPMMP9MMP8ALDH1A1ALOX15 | |
| SCHEMBL23978397 | 0.77 | MAPT (0.64) | MMP13SCDAPPMMP2MMP9 | |
| SCHEMBL13265793 | 0.75 | SCD (0.76) | MMP13SCDALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL6124085 | 0.75 | SCD (0.49) | MMP13SCDAPPMMP2MMP9 | |
| SCHEMBL1807571 | 0.75 | RAB9A (0.62) | APPALDH1A1ALOX15MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9833458-B2 | Thioflavin derivatives for use in the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2017-12-05 | — | — | US | disclosed |
| US-20150190400-A1 | THIOFLAVIN DERIVATIVES FOR USE IN THE ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2015-07-09 | — | — | US | disclosed |
| EP-2264018-B1 | Thioflavin derivatives for use in the diagnosis of Alzheimer's disease | UNIV PITTSBURGH (US) | 2015-02-11 | — | — | EP | disclosed |
| EP-1334091-B1 | THIOFLAVIN DERIVATIVES AND THEIR USE IN DIAGNOSIS AND THERAPY OF ALZHEIMER'S DISEASE | UNIV PITTSBURGH (US) | 2012-09-19 | — | — | EP | disclosed |
| US-20120095235-A1 | THIOFLAVIN DERIVATES FOR USE IN THE ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION | UNIVERSITY OF PITTSBURGH -- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2012-04-19 | — | — | US | disclosed |
| EP-2264018-A2 | Thioflavin derivatives for use in the diagnosis of Alzheimer's disease | University of Pittsburgh of the Commonwealth System of Higher Education (US) | 2010-12-22 | — | — | EP | disclosed |
| US-20080154042-A1 | THIOFLAVIN DERIVATIVES FOR USE IN THE ANTEMORTEM DIAGNOSIS OF ALZHEIMERS DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION | UNIVERSITY OF PITTSBURGH | 2008-06-26 | — | — | US | disclosed |
| US-7351401-B2 | Thioflavin derivatives for use in the antemortem diagnosis of Alzheimers disease and in vivo imaging and prevention of amyloid deposition | UNIVERSITY OF PITTSBURGH (US) | 2008-04-01 | — | — | US | disclosed |
| CN-1285582-C | Thioflavin derivatives and their use in diagnosis and theraphy of alzheimer's disease | UNIV PITTSBURGH (US) | 2006-11-22 | — | — | CN | disclosed |
| US-20050043377-A1 | Thioflavin derivatives for use in the antemortem diagnosis of alzheimers disease and in vivo imaging and prevention of amyloid deposition | UNIVERSITY OF PITTSBURGH | 2005-02-24 | — | — | US | disclosed |
| CN-1535268-A | Thioflavin derivatives for antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposits | ƥ�ȱ���ѧ | 2004-10-06 | — | — | CN | disclosed |
| EP-1334091-A2 | THIOFLAVIN DERIVATIVES AND THEIR USE IN DIAGNOSIS AND THERAPY OF ALZHEIMER'S DISEASE | UNIVERSITY OF PITTSBURGH (US) | 2003-08-13 | — | — | EP | disclosed |
| US-20020133019-A1 | Thioflavin derivatives for use in antemortem diagnosis of alzheimer's disease and vivo imaging and prevention of amyloid deposition | PITTSBURGH, UNIVERSITY OF | 2002-09-19 | — | — | US | disclosed |
| WO-2002016333-A2 | THIOFLAVIN DERIVATIVES AND THEIR USE IN DIAGNOSIS AND THERAPHY OF ALZHEIMER'S DISEASE | UNIVERSITY OF PITTSBURGH (US) | 2002-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095235-A1 | THIOFLAVIN DERIVATES FOR USE IN THE ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION | APP, MAPT, PSEN2 | MMP13 3889/4885SCD 1301/4885APP 1/4885 |
| US-20080154042-A1 | THIOFLAVIN DERIVATIVES FOR USE IN THE ANTEMORTEM DIAGNOSIS OF ALZHEIMERS DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION | APP, PSEN2, MAPT | MMP13 4039/4885SCD 1867/4885APP 1/4885 |
| US-20150190400-A1 | THIOFLAVIN DERIVATIVES FOR USE IN THE ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION | APP, PSEN2, MAPT | MMP13 4077/4885SCD 1846/4885APP 1/4885 |
| US-20020133019-A1 | Thioflavin derivatives for use in antemortem diagnosis of alzheimer's disease and vivo imaging and prevention of amyloid deposition | APP, PSEN2, MAPT | MMP13 4137/4885SCD 2059/4885APP 1/4885 |
| US-20050043377-A1 | Thioflavin derivatives for use in the antemortem diagnosis of alzheimers disease and in vivo imaging and prevention of amyloid deposition | APP, PSEN2, MAPT | MMP13 4039/4885SCD 1867/4885APP 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.