Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21177631 | 0.96 | POLB (0.54) | POLBALDH1A1KDM4EGAAKMT2A | |
| SCHEMBL9886021 | 0.91 | KDM4E (0.52) | POLBALDH1A1KDM4EGAAKMT2A | |
| SCHEMBL21189459 | 0.91 | KMT2A (0.53) | POLBALDH1A1GAAKMT2ANPC1 | |
| SCHEMBL21812892 | 0.84 | L3MBTL3 (0.44) | POLBALDH1A1GAAKMT2ANPC1 | |
| SCHEMBL18274844 | 0.83 | CNR1 (0.46) | POLBALDH1A1KDM4EKMT2AGLA | |
| SCHEMBL14644842 | 0.83 | MAPT (0.48) | ALDH1A1KDM4EMAPTHTT | |
| SCHEMBL21177182 | 0.83 | POLB (0.39) | POLBALDH1A1KDM4EGAAKMT2A | |
| SCHEMBL21177371 | 0.83 | POLB (0.39) | POLBALDH1A1KDM4EGAA | |
| SCHEMBL21177373 | 0.83 | POLB (0.39) | POLBALDH1A1KDM4EGAA | |
| SCHEMBL21177388 | 0.82 | RAB9A (0.41) | POLBALDH1A1GAAKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019141694-A1 | PI4KIIIBETA INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-07-25 | — | — | WO | disclosed |