Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.64 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.64 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.64 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.64 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.64 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.64 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.64 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29363132 | 0.95 | HSD17B10 (0.67) | HSD17B10ALOX15PDK1PDK2PDK3 | |
| SCHEMBL15137271 | 0.95 | HSD17B10 (0.67) | HSD17B10ALOX15PDK1PDK2PDK3 | |
| SCHEMBL31152669 | 0.95 | HSD17B10 (0.67) | HSD17B10ALOX15PDK1PDK2PDK3 | |
| SCHEMBL15072078 | 0.95 | HSD17B10 (0.67) | HSD17B10ALOX15PDK1PDK2PDK3 | |
| SCHEMBL123110 | 0.95 | HSD17B10 (0.67) | HSD17B10ALOX15PDK1PDK2PDK3 | |
| SCHEMBL15072071 | 0.88 | HSD17B10 (0.67) | HSD17B10ALOX15PDK1PDK2PDK3 | |
| SCHEMBL15076162 | 0.87 | HSD17B10 (0.66) | HSD17B10ALOX15PDK1PDK2PDK3 | |
| SCHEMBL24412724 | 0.86 | HSD17B10 (0.65) | HSD17B10ALOX15PDK1PDK2PDK3 | |
| SCHEMBL13454791 | 0.86 | HSD17B10 (0.65) | HSD17B10ALOX15PDK1PDK2PDK3 | |
| SCHEMBL17014612 | 0.85 | HSD17B10 (0.64) | HSD17B10ALOX15PDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120093896-A1 | USE OF NANODISPERSIONS TO PROTECT WATER-SOLUBLE INGREDIENTS IN COSMETIC END FORMULATIONS | CIBA CORPORATION (US) | 2012-04-19 | — | — | US | disclosed |
| US-20100111884-A1 | UV ABSORBER FORMULATIONS | CIBA CORPORATION (US) | 2010-05-06 | — | — | US | disclosed |
| EP-2170250-A1 | USE OF NANODISPERSIONS TO PROTECT WATER-SOLUBLE INGREDIENTS IN COSMETIC END FORMULATIONS | BASF SE (DE) | 2010-04-07 | — | — | EP | disclosed |
| EP-2099530-A1 | UV ABSORBER FORMULATIONS | Ciba Holding Inc. (CH) | 2009-09-16 | — | — | EP | disclosed |
| US-20090196894-A1 | Self Tanning Composition | CIBA CORP. | 2009-08-06 | — | — | US | disclosed |
| WO-2009016064-A1 | USE OF NANODISPERSIONS TO PROTECT WATER-SOLUBLE INGREDIENTS IN COSMETIC END FORMULATIONS | BASF SE (CH) | 2009-02-05 | — | — | WO | disclosed |
| WO-2008080892-A1 | UV ABSORBER FORMULATIONS | CIBA HOLDING INC. (CH) | 2008-07-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100111884-A1 | UV ABSORBER FORMULATIONS | C1R, C1S, C9 | HSD17B10 1028/4885ALOX15 1518/4885PDK1 3479/4885 |
| US-20090196894-A1 | Self Tanning Composition | C9, KRT18, F12 | HSD17B10 2267/4885ALOX15 2314/4885PDK1 797/4885 |
| US-20120093896-A1 | USE OF NANODISPERSIONS TO PROTECT WATER-SOLUBLE INGREDIENTS IN COSMETIC END FORMULATIONS | CUTA, PROC, RBP1 | HSD17B10 929/4885ALOX15 344/4885PDK1 864/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.