Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBLB | Q13191 | 16/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29866714 | 0.87 | HCRTR1 (0.44) | CBLB | |
| SCHEMBL21200852 | 0.82 | CBLB (0.70) | CBLB | |
| SCHEMBL29866670 | 0.82 | CBLB (0.70) | CBLB | |
| SCHEMBL21200967 | 0.82 | MEN1 (0.35) | CBLBPOLB | |
| SCHEMBL21200478 | 0.79 | CBLB (0.37) | CBLB | |
| SCHEMBL29867316 | 0.79 | CBLB (0.37) | CBLB | |
| SCHEMBL21200198 | 0.76 | CBLB (0.66) | CBLBPOLBMAPT | |
| SCHEMBL29841650 | 0.75 | CBLB (0.37) | CBLB | |
| SCHEMBL21201152 | 0.75 | CBLB (0.55) | CBLBPOLBMAPTLMNAGAA | |
| SCHEMBL21201167 | 0.74 | CBLB (0.69) | CBLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3743063-A1 | INHIBITORS OF CBL-B AND METHODS OF USE THEREOF | Nurix Therapeutics, Inc. (US) | 2020-12-02 | — | — | EP | disclosed |
| WO-2019148005-A1 | INHIBITORS OF CBL-B AND METHODS OF USE THEREOF | NURIX THERAPEUTICS, INC. (US) | 2019-08-01 | — | — | WO | disclosed |