Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 4/20 | 0.34 |
| ▸ | CBLB | Q13191 | 3/20 | 0.34 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.33 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.33 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29866989 | 0.87 | HCRTR1 (0.45) | MEN1CYP2C19KMT2A | |
| SCHEMBL21201116 | 0.82 | CBLB (0.44) | POLBCBLB | |
| SCHEMBL21200369 | 0.75 | AKR1C3 (0.40) | MEN1CYP2C9CYP2C19HTTKMT2A | |
| SCHEMBL21201248 | 0.71 | ALDH1A1 (0.42) | MEN1CYP1A2POLBCYP2D6CYP2C9 | |
| SCHEMBL29866714 | 0.69 | HCRTR1 (0.44) | CBLB | |
| SCHEMBL21200277 | 0.67 | ALDH1A1 (0.43) | MEN1CYP1A2POLBCYP2D6CYP2C9 | |
| SCHEMBL25214857 | 0.64 | LMNA (0.51) | MEN1POLBHTTKMT2ASMN1; SMN2 | |
| SCHEMBL24028223 | 0.62 | KMT2A (0.48) | MEN1CYP1A2POLBCYP2C9CYP2C19 | |
| SCHEMBL11858223 | 0.60 | GPR35 (0.67) | MEN1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL28148358 | 0.60 | KMT2A (0.42) | MEN1CYP1A2POLBCYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3743063-A1 | INHIBITORS OF CBL-B AND METHODS OF USE THEREOF | Nurix Therapeutics, Inc. (US) | 2020-12-02 | — | — | EP | disclosed |
| WO-2019148005-A1 | INHIBITORS OF CBL-B AND METHODS OF USE THEREOF | NURIX THERAPEUTICS, INC. (US) | 2019-08-01 | — | — | WO | disclosed |