Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21198678 | 0.90 | HTT (0.56) | HTTALDH1A1NPSR1TDP1SIGMAR1 | |
| SCHEMBL3823611 | 0.79 | HTT (0.70) | HTTALDH1A1NPSR1TDP1KMT2A | |
| SCHEMBL4237286 | 0.77 | SIGMAR1 (0.55) | ALDH1A1SIGMAR1KMT2A | |
| SCHEMBL25062295 | 0.77 | GAA (0.52) | HTTTDP1SIGMAR1KMT2AMAPK1 | |
| SCHEMBL13841169 | 0.76 | TDP1 (0.62) | HTTALDH1A1TDP1KMT2ANPC1 | |
| SCHEMBL25062307 | 0.75 | HTT (0.69) | HTTALDH1A1TDP1SIGMAR1KMT2A | |
| SCHEMBL29043226 | 0.75 | KMT2A (0.56) | HTTALDH1A1TDP1KMT2APOLB | |
| SCHEMBL28919028 | 0.74 | PKM (0.51) | HTTALDH1A1TDP1KMT2APOLB | |
| SCHEMBL546627 | 0.73 | HTT (0.77) | HTTALDH1A1NPSR1TDP1POLB | |
| SCHEMBL21044234 | 0.73 | HTT (0.70) | HTTALDH1A1NPSR1TDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3743421-A1 | COMPOUNDS | Oxford University Innovation Limited (GB) | 2020-12-02 | — | — | EP | claimed |
| WO-2019145718-A1 | COMPOUNDS | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2019-08-01 | — | — | WO | claimed |
| EP-3743421-A1 | COMPOUNDS | Oxford University Innovation Limited (GB) | 2020-12-02 | — | — | EP | disclosed |
| WO-2019145718-A1 | COMPOUNDS | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2019-08-01 | — | — | WO | disclosed |