Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 11/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL211523 | 0.93 | CTSK (0.38) | ABL1MAPK1METCTSKALDH1A1 | |
| SCHEMBL2840754 | 0.93 | CTSK (0.38) | ABL1MAPK1METCTSKALDH1A1 | |
| SCHEMBL210584 | 0.93 | ABL1 (0.37) | ABL1MAPK1RPS6KA1CARM1PRMT6 | |
| SCHEMBL2843927 | 0.93 | ABL1 (0.37) | ABL1MAPK1RPS6KA1CARM1PRMT6 | |
| SCHEMBL209967 | 0.86 | CTSK (0.37) | ABL1MAPK1CTSKALDH1A1RAB9A | |
| SCHEMBL211681 | 0.86 | ABL1 (0.34) | ABL1MAPK1RPS6KA1METCTSK | |
| SCHEMBL210177 | 0.84 | ABL1 (0.35) | ABL1MAPK1RPS6KA1CTSK | |
| SCHEMBL212747 | 0.83 | ABL1 (0.33) | ABL1MAPK1RPS6KA1METCTSK | |
| SCHEMBL212350 | 0.81 | MAOB (0.35) | CTSKRAB9A | |
| SCHEMBL4343074 | 0.80 | ABL1 (0.34) | ABL1MAPK1RPS6KA1METCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |