Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | GCG | P01275 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | PPARA | Q07869 | 2/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL211523 | 1.00 | CTSK (0.38) | CTSKGCGABL1NOTUMFOLH1 | |
| SCHEMBL212050 | 0.93 | ABL1 (0.38) | CTSKABL1MAPK1RAB9AALDH1A1 | |
| SCHEMBL209967 | 0.92 | CTSK (0.37) | CTSKGCGABL1NOTUMFOLH1 | |
| SCHEMBL210584 | 0.86 | ABL1 (0.37) | CTSKABL1MAPK1P2RX7TDP1 | |
| SCHEMBL2843927 | 0.86 | ABL1 (0.37) | CTSKABL1MAPK1P2RX7TDP1 | |
| SCHEMBL212478 | 0.85 | CTSK (0.36) | CTSKGCGABL1NOTUMFOLH1 | |
| SCHEMBL212350 | 0.85 | MAOB (0.35) | CTSKFOLH1RAB9AKDM4EP2RX7 | |
| SCHEMBL2840546 | 0.83 | CTSK (0.39) | CTSKABL1NOTUMPKMMAPK1 | |
| SCHEMBL2837038 | 0.83 | CTSK (0.39) | CTSKGCGABL1NOTUMPKM | |
| SCHEMBL214679 | 0.82 | CTSK (0.37) | CTSKGCGABL1NOTUMFOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195328-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Incorporated (US) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009023193-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2009-02-19 | — | — | WO | disclosed |