Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 16/20 | 0.49 |
| ▸ | XIAP | P98170 | 1/20 | 0.33 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22226810 | 0.86 | ACHE (0.47) | ACHECHRNB2CHRNA4GRM5 | |
| SCHEMBL31619906 | 0.74 | ACHE (0.58) | ACHE | |
| SCHEMBL6936371 | 0.70 | ACHE (0.54) | ACHE | |
| SCHEMBL424868 | 0.70 | ELANE (0.38) | XIAPBIRC2CHRNB2CHRNA4 | |
| SCHEMBL13957818 | 0.70 | CYP19A1 (0.30) | XIAPBIRC2CHRNB2CHRNA4 | |
| SCHEMBL31529876 | 0.70 | ELANE (0.38) | XIAPBIRC2CHRNB2CHRNA4 | |
| SCHEMBL11663934 | 0.69 | ACHE (0.51) | ACHE | |
| SCHEMBL21205776 | 0.68 | CHRNB2 (0.40) | XIAPBIRC2CHRNB2CHRNA4GRM5 | |
| SCHEMBL8091521 | 0.68 | ACHE (0.69) | ACHE | |
| SCHEMBL20692255 | 0.68 | ACHE (0.59) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055288-B1 | ANTIDIABETIC TRICYCLIC COMPOUNDS | MERCK SHARP & DOHME (US) | 2020-12-16 | — | — | EP | disclosed |
| EP-3068768-B1 | ANTIDIABETIC TRICYCLIC COMPOUNDS | MERCK SHARP & DOHME (US) | 2019-07-31 | — | — | EP | disclosed |