Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.68 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.68 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 3/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21206519 | 0.86 | PDCD1 (0.54) | PDCD1CD274ATMCYP1A2MAPK1 | |
| SCHEMBL21206406 | 0.86 | PDCD1 (0.54) | PDCD1CD274ATMCYP1A2MAPK1 | |
| SCHEMBL21199640 | 0.82 | PDCD1 (1.00) | PDCD1CD274ATMSMN1; SMN2MEN1 | |
| SCHEMBL8628664 | 0.81 | ATM (0.68) | ATMCYP1A2MAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL3439885 | 0.70 | ATM (0.62) | ATMCYP1A2MAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL11490504 | 0.70 | CYP1A2 (0.55) | ATMCYP1A2MAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL22856518 | 0.70 | S1PR1 (0.43) | PDCD1CD274L3MBTL1MEN1KMT2A | |
| SCHEMBL949323 | 0.69 | ALDH1A1 (0.61) | ATMCYP1A2MAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL4727189 | 0.68 | SMN1; SMN2 (0.68) | CYP1A2MAPK1SMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL24926663 | 0.68 | PDCD1 (0.41) | PDCD1CD274ATMCYP1A2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210053972-A1 | COMPOUNDS USEFUL AS IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY | 2021-02-25 | — | — | US | disclosed |
| WO-2019147662-A1 | 2,8-DIACYL-2,8-DIAZASPIRO[5.5]UNDECANE COMPOUNDS USEFUL AS IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-08-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210053972-A1 | COMPOUNDS USEFUL AS IMMUNOMODULATORS | CD74, HLA-DRB1, CD47 | PDCD1 161/4885CD274 52/4885ATM 2610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.