Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 11/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.39 |
| ▸ | GSK3B | P49841 | 6/20 | 0.39 |
| ▸ | WNT1 | P04628 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CLK3 | P49761 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL211864 | 1.00 | ABL1 (0.40) | ABL1DYRK1AGSK3BWNT1CLK2 | |
| SCHEMBL213151 | 0.89 | ABL1 (0.42) | ABL1DYRK1AGSK3BWNT1CLK2 | |
| SCHEMBL212870 | 0.87 | NOTUM (0.46) | ABL1NOTUM | |
| SCHEMBL213202 | 0.87 | NOTUM (0.46) | ABL1NOTUM | |
| SCHEMBL213815 | 0.84 | ABL1 (0.41) | ABL1DYRK1AGSK3BMAP4K1 | |
| SCHEMBL210974 | 0.83 | ABL1 (0.40) | ABL1DYRK1AGSK3BWNT1CLK2 | |
| SCHEMBL214063 | 0.75 | NOTUM (0.47) | ABL1NOTUMMAP4K1 | |
| SCHEMBL212153 | 0.75 | PIN1 (0.34) | ABL1DYRK1AGSK3BWNT1 | |
| SCHEMBL212152 | 0.75 | PIN1 (0.34) | ABL1DYRK1AGSK3BWNT1 | |
| SCHEMBL209916 | 0.73 | PIN1 (0.34) | ABL1DYRK1AGSK3BWNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |