Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 13/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.37 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL213835 | 0.86 | KDM4E (0.47) | LTB4REGLN1CYSLTR2CYSLTR1 | |
| SCHEMBL213605 | 0.85 | KDM4E (0.46) | LTB4REGLN1CYSLTR2CYSLTR1 | |
| SCHEMBL210974 | 0.84 | ABL1 (0.40) | ABL1GSK3BDYRK1A | |
| SCHEMBL211864 | 0.84 | ABL1 (0.40) | ABL1GSK3BDYRK1AMAP4K1 | |
| SCHEMBL212066 | 0.84 | ABL1 (0.40) | ABL1GSK3BDYRK1AMAP4K1 | |
| SCHEMBL215046 | 0.82 | ALDH1A1 (0.48) | ABL1LTB4REGLN1CYSLTR2CYSLTR1 | |
| SCHEMBL213151 | 0.81 | ABL1 (0.42) | ABL1GSK3BDYRK1AMAP4K1 | |
| SCHEMBL2842110 | 0.76 | ABL1 (0.52) | ABL1GSK3BDYRK1A | |
| SCHEMBL13943717 | 0.73 | ABL1 (0.37) | ABL1GSK3BDYRK1A | |
| SCHEMBL13942995 | 0.72 | ABL1 (0.40) | ABL1GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |