Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 4/20 | 0.39 |
| ▸ | ACHE | P22303 | 3/20 | 0.39 |
| ▸ | ABL1 | P00519 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL212870 | 1.00 | NOTUM (0.46) | NOTUMMTORWNT3ACHEK1KDM4E | |
| SCHEMBL214063 | 0.88 | NOTUM (0.47) | NOTUMMTORWNT3ACHEK1KDM4E | |
| SCHEMBL211864 | 0.87 | ABL1 (0.40) | NOTUMABL1 | |
| SCHEMBL212066 | 0.87 | ABL1 (0.40) | NOTUMABL1 | |
| SCHEMBL213578 | 0.85 | NOTUM (0.44) | NOTUMMTORWNT3ACHEK1KDM4E | |
| SCHEMBL213675 | 0.84 | NOTUM (0.49) | NOTUMMTORWNT3ACHEK1KDM4E | |
| SCHEMBL213605 | 0.83 | KDM4E (0.46) | NOTUMWNT3ACHEK1KDM4EALDH1A1 | |
| SCHEMBL213835 | 0.82 | KDM4E (0.47) | NOTUMMTORWNT3ACHEK1KDM4E | |
| SCHEMBL2837602 | 0.81 | NOTUM (0.46) | NOTUMMTORWNT3ACHEK1KDM4E | |
| SCHEMBL215046 | 0.81 | ALDH1A1 (0.48) | NOTUMMTORWNT3ACHEK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |