Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14155652 | 0.81 | IKBKE (0.34) | KDM4EL3MBTL1DEGS1RAB9ASMN1; SMN2 | |
| SCHEMBL13825386 | 0.81 | CHRNB2 (0.40) | KDM4ERAB9AHRH3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5691852 | 0.80 | RRM2 (0.38) | KDM4EL3MBTL1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL28280233 | 0.79 | TDP1 (0.32) | KDM4EL3MBTL1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL12020150 | 0.76 | HCAR3 (0.46) | KDM4EL3MBTL1DEGS1RAB9ASMN1; SMN2 | |
| SCHEMBL14416655 | 0.75 | HCAR3 (0.53) | KDM4EL3MBTL1DEGS1RAB9ASMN1; SMN2 | |
| SCHEMBL211249 | 0.75 | RAB9A (0.55) | KDM4EL3MBTL1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL406014 | 0.75 | KDM4E (0.47) | KDM4EL3MBTL1DEGS1RAB9ASMN1; SMN2 | |
| SCHEMBL11466907 | 0.74 | DEGS1 (0.56) | DEGS1RAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL13662053 | 0.73 | PTGS1 (0.46) | KDM4EL3MBTL1DEGS1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |