Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 5/20 | 0.31 |
| ▸ | CTSL | P07711 | 2/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 2/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14744271 | 0.73 | KMT2A (0.38) | KMT2AMEN1GAAALDH1A1TSHR | |
| SCHEMBL25243412 | 0.68 | MEN1 (0.41) | KMT2AMEN1GAAAAK1ALDH1A1 | |
| SCHEMBL4519114 | 0.66 | CTSL (0.42) | KMT2AMEN1GAAALDH1A1TSHR | |
| SCHEMBL27566114 | 0.66 | CTSL (0.42) | KMT2AMEN1GAAALDH1A1TSHR | |
| SCHEMBL14744085 | 0.65 | CTSK (0.41) | KMT2AMEN1GAAALDH1A1EPHX1 | |
| SCHEMBL17079746 | 0.65 | MEN1 (0.47) | KMT2AMEN1GAAL3MBTL1SYK | |
| SCHEMBL24261281 | 0.65 | KMT2A (0.42) | KMT2AMEN1GAAALDH1A1TSHR | |
| SCHEMBL14631440 | 0.65 | MEN1 (0.45) | KMT2AMEN1GAAAAK1ALDH1A1 | |
| SCHEMBL13109049 | 0.65 | MEN1 (0.61) | KMT2AMEN1GAAAAK1SYK | |
| SCHEMBL13109033 | 0.65 | MEN1 (0.61) | KMT2AMEN1GAAAAK1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019148132-A1 | GCN2 INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2019-08-01 | — | — | WO | disclosed |