Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 3/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4519114 | 0.80 | CTSL (0.42) | KMT2AMEN1GAAALDH1A1TSHR | |
| SCHEMBL27566114 | 0.80 | CTSL (0.42) | KMT2AMEN1GAAALDH1A1TSHR | |
| SCHEMBL8173021 | 0.76 | PCSK9 (0.38) | KMT2AMEN1GAAALDH1A1TSHR | |
| SCHEMBL2486525 | 0.76 | USP2 (0.44) | KMT2AMEN1GAAALDH1A1CTSK | |
| SCHEMBL14744085 | 0.76 | CTSK (0.41) | KMT2AMEN1GAAALDH1A1EPHX1 | |
| SCHEMBL4723757 | 0.75 | PIK3CD (0.38) | KMT2AMEN1GAAALDH1A1TSHR | |
| SCHEMBL13052234 | 0.75 | KMT2A (0.43) | KMT2AMEN1GAAALDH1A1TSHR | |
| SCHEMBL21210017 | 0.73 | KMT2A (0.34) | KMT2AMEN1GAAALDH1A1TSHR | |
| SCHEMBL18233672 | 0.72 | CACNA1H (0.49) | KMT2AMEN1GAAALDH1A1TSHR | |
| SCHEMBL18233674 | 0.72 | CACNA1H (0.49) | KMT2AMEN1GAAALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013030138-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |