Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 2/20 | 0.34 |
| ▸ | WEE1 | P30291 | 3/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21217527 | 0.88 | MKNK1 (0.40) | ROCK2MKNK1KDRROCK1MAPKAPK2 | |
| SCHEMBL21217824 | 0.88 | ROCK2 (0.44) | CACNA2D1ROCK2MKNK1KDRROCK1 | |
| SCHEMBL24094335 | 0.88 | ROCK2 (0.38) | CACNA2D1ROCK2DHODHMKNK1KDR | |
| SCHEMBL24094099 | 0.87 | ROCK2 (0.42) | ROCK2DHODHKDRMEN1KMT2A | |
| SCHEMBL21217528 | 0.86 | ROCK1 (0.37) | ROCK2DHODHMEN1KMT2ANPC1 | |
| SCHEMBL21217621 | 0.84 | TNIK (0.41) | ROCK2KDRNPC1RAB9AROCK1 | |
| SCHEMBL21217817 | 0.84 | ROCK2 (0.37) | ROCK2KDRROCK1MAPKAPK2RET | |
| SCHEMBL21217850 | 0.84 | ROCK2 (0.38) | ROCK2DHODHMEN1KMT2ANPC1 | |
| SCHEMBL21217863 | 0.84 | ROCK1 (0.40) | ROCK2ROCK1CLK2DYRK1ACLK4 | |
| SCHEMBL24094350 | 0.83 | PIK3CA (0.34) | ROCK2MKNK1KDRMAPKAPK2WEE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019145729-A9 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | REDX PHARMA PLC (GB) | 2020-07-30 | — | — | WO | disclosed |
| WO-2019145729-A1 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | REDX PHARMA PLC (GB) | 2019-08-01 | — | — | WO | disclosed |