Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 8/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | PRKCG | P05129 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21217528 | 0.92 | ROCK1 (0.37) | ROCK2ROCK1DHODHNPC1MEN1 | |
| SCHEMBL21217850 | 0.90 | ROCK2 (0.38) | ROCK2ROCK1DHODHNPC1MEN1 | |
| SCHEMBL21217863 | 0.90 | ROCK1 (0.40) | ROCK2ROCK1CLK2CSNK2A1DYRK1A | |
| SCHEMBL21217818 | 0.89 | MKNK1 (0.40) | ROCK2ROCK1 | |
| SCHEMBL24094323 | 0.88 | ROCK2 (0.48) | ROCK2ROCK1DHODHNPC1MEN1 | |
| SCHEMBL24094335 | 0.88 | ROCK2 (0.38) | ROCK2ROCK1DHODHNPC1MEN1 | |
| SCHEMBL21217774 | 0.87 | CACNA2D1 (0.37) | ROCK2ROCK1DHODHNPC1MEN1 | |
| SCHEMBL21217527 | 0.86 | MKNK1 (0.40) | ROCK2ROCK1KDREGFRERBB2 | |
| SCHEMBL21217824 | 0.86 | ROCK2 (0.44) | ROCK2ROCK1KDR | |
| SCHEMBL24094285 | 0.86 | NPC1 (0.40) | ROCK2ROCK1DHODHNPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4026834-A1 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | Redx Pharma Plc (GB) | 2022-07-13 | — | — | EP | disclosed |
| EP-3743420-B1 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | REDX PHARMA PLC (GB) | 2021-12-15 | — | — | EP | disclosed |