Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 10/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21217774 | 0.88 | CACNA2D1 (0.37) | ROCK2ROCK1MAPKAPK2KDRDHODH | |
| SCHEMBL24094099 | 0.88 | ROCK2 (0.42) | ROCK2ROCK1MAPK1KDRDHODH | |
| SCHEMBL21217816 | 0.87 | MEN1 (0.40) | ROCK2ROCK1DHODHMEN1KMT2A | |
| SCHEMBL21217527 | 0.87 | MKNK1 (0.40) | ROCK2ROCK1MAPKAPK2KDRMKNK1 | |
| SCHEMBL21217824 | 0.87 | ROCK2 (0.44) | ROCK2ROCK1MAPKAPK2KDRCACNA2D1 | |
| SCHEMBL21217528 | 0.86 | ROCK1 (0.37) | ROCK2ROCK1DHODHMEN1KMT2A | |
| SCHEMBL21217850 | 0.84 | ROCK2 (0.38) | ROCK2ROCK1DHODHMEN1KMT2A | |
| SCHEMBL21217863 | 0.84 | ROCK1 (0.40) | ROCK2ROCK1CLK4 | |
| SCHEMBL21217626 | 0.84 | ROCK2 (0.37) | ROCK2ROCK1MAPK1DHODH | |
| SCHEMBL24094285 | 0.83 | NPC1 (0.40) | ROCK2ROCK1KDRDHODHMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3743420-B1 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | REDX PHARMA PLC (GB) | 2021-12-15 | — | — | EP | disclosed |