Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | POLL | Q9UGP5 | 1/20 | 0.35 |
| ▸ | UGT2B17 | O75795 | 2/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | CCR1 | P32246 | 2/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25693008 | 0.89 | GRM5 (0.52) | GRM5DRD2DRD1UGT2B17AURKA | |
| SCHEMBL14931524 | 0.89 | GRM5 (0.52) | GRM5DRD2DRD1UGT2B17AURKA | |
| SCHEMBL6845116 | 0.78 | DRD2 (0.38) | DRD2DRD1PDK2PDK4HCRTR1 | |
| SCHEMBL10238794 | 0.78 | DRD2 (0.38) | DRD2DRD1PDK2PDK4HCRTR1 | |
| SCHEMBL6845166 | 0.77 | DRD2 (0.37) | DRD2DRD1PDK2PDK4HCRTR1 | |
| SCHEMBL21223419 | 0.77 | DRD2 (0.37) | DRD2DRD1PDK2PDK4HCRTR1 | |
| SCHEMBL6845212 | 0.77 | DRD2 (0.37) | DRD2DRD1PDK2PDK4HCRTR1 | |
| SCHEMBL21223327 | 0.77 | GRM5 (0.41) | GRM5POLLAURKADAPK3PRKD3 | |
| SCHEMBL31183085 | 0.77 | GRM5 (0.41) | GRM5POLLAURKADAPK3PRKD3 | |
| SCHEMBL31137302 | 0.77 | GRM5 (0.41) | GRM5POLLAURKADAPK3PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220213076-A1 | GHRELIN O-ACYLTRANSFERASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2022-07-07 | — | — | US | disclosed |
| US-20220213076-A1 | GHRELIN O-ACYLTRANSFERASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2022-07-07 | — | — | US | disclosed |
| US-11312709-B2 | Ghrelin O-acyltransferase inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2022-04-26 | — | — | US | disclosed |
| US-11312709-B2 | Ghrelin O-acyltransferase inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2022-04-26 | — | — | US | disclosed |
| US-20210053955-A1 | GHRELIN O-ACYLTRANSFERASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2021-02-25 | — | — | US | disclosed |
| US-20210053955-A1 | GHRELIN O-ACYLTRANSFERASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2021-02-25 | — | — | US | disclosed |
| EP-3749304-A1 | GHRELIN O-ACYLTRANSFERASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2020-12-16 | — | — | EP | disclosed |
| WO-2019149959-A1 | GHRELIN O-ACYLTRANSFERASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-08-08 | — | — | WO | disclosed |
| WO-2019149959-A1 | GHRELIN O-ACYLTRANSFERASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-08-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220213076-A1 | GHRELIN O-ACYLTRANSFERASE INHIBITORS | MBOAT4, GIPR, GPR119 | GRM5 203/4885DRD2 864/4885DRD1 1254/4885 |
| US-11312709-B2 | Ghrelin O-acyltransferase inhibitors | MBOAT4, GIPR, GPR119 | GRM5 203/4885DRD2 864/4885DRD1 1254/4885 |
| US-20210053955-A1 | GHRELIN O-ACYLTRANSFERASE INHIBITORS | MBOAT4, GIPR, GPR119 | GRM5 203/4885DRD2 864/4885DRD1 1254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.