Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.47 |
| ▸ | MRE11 | P49959 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL21224199 | 1.00 | HDAC6 (0.57) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL21224715 | 0.94 | HDAC6 (0.63) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL21224560 | 0.94 | HDAC6 (0.63) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL22970146 | 0.88 | HDAC6 (0.67) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL22305385 | 0.82 | MAPT (0.54) | HDAC6MAPTELOVL1MEN1KMT2A | |
| SCHEMBL21224492 | 0.82 | HDAC6 (0.67) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL21224494 | 0.82 | HDAC6 (0.67) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL30657979 | 0.81 | HDAC6 (0.49) | HDAC6HDAC4MRE11 | |
| SCHEMBL23704796 | 0.81 | KDM4E (0.54) | HDAC6MAPTMRE11MEN1KMT2A | |
| SCHEMBL23704797 | 0.81 | KDM4E (0.54) | HDAC6MAPTMRE11MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230138480-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2023-05-04 | — | — | US | disclosed |
| US-20210038611-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2021-02-11 | — | — | US | disclosed |
| CN-112153984-A | Compound and use thereof | 福宏治疗公司 | 2020-12-29 | — | — | CN | disclosed |
| EP-3746124-A1 | COMPOUNDS AND USES THEREOF | Foghorn Therapeutics Inc. (US) | 2020-12-09 | — | — | EP | disclosed |
| WO-2019152437-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2019-08-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230138480-A1 | COMPOUNDS AND USES THEREOF | VHL, CLN6, TFEB | HDAC6 86/4885HDAC3 231/4885HDAC4 152/4885 |
| US-20210038611-A1 | COMPOUNDS AND USES THEREOF | VHL, CLN6, TFEB | HDAC6 86/4885HDAC3 231/4885HDAC4 152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.