SCHEMBL2122883

SCHEMBL2122883

Cc1cc(C)c(C2C(=O)C3C4CCC(O4)C3C2=O)c(C)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.40
TDP1 Q9NUW8 2/20 0.38
KDM4E B2RXH2 2/20 0.38
GMNN O75496 1/20 0.38
PPM1B O75688 1/20 0.38
LMNA P02545 1/20 0.38
PPP1CC P36873 1/20 0.38
TFPI2 P48307 1/20 0.38
RAB9A P51151 1/20 0.38
PPP5C P53041 1/20 0.38
PPP1CA P62136 1/20 0.38
PMP22 Q01453 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
TP53 P04637 1/20 0.38
CYP2D6 P10635 1/20 0.38
NFKB1 P19838 1/20 0.38
THPO P40225 1/20 0.38
MEN1 O00255 1/20 0.31
GAPDH P04406 1/20 0.31
POLB P06746 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16196649 0.87 L3MBTL1 (0.38) L3MBTL1TDP1KDM4EGMNNPPM1B
SCHEMBL516059 0.87 L3MBTL1 (0.38) L3MBTL1TDP1KDM4EGMNNPPM1B
SCHEMBL6727399 0.85 L3MBTL1 (0.38) L3MBTL1TDP1KDM4EGMNNPPM1B
SCHEMBL18873798 0.85 L3MBTL1 (0.38) L3MBTL1TDP1KDM4EGMNNPPM1B
SCHEMBL15001081 0.83 L3MBTL1 (0.35) L3MBTL1TDP1KDM4EGMNNPPM1B
SCHEMBL2122933 0.82 LMNA (0.36) L3MBTL1TDP1KDM4EGMNNPPM1B
SCHEMBL18874378 0.82 L3MBTL1 (0.35) L3MBTL1TDP1KDM4EGMNNPPM1B
SCHEMBL21938530 0.82 L3MBTL1 (0.35) L3MBTL1TDP1KDM4EGMNNPPM1B
SCHEMBL22906311 0.82 L3MBTL1 (0.35) L3MBTL1TDP1KDM4EGMNNPPM1B
SCHEMBL15001080 0.82 L3MBTL1 (0.35) L3MBTL1TDP1KDM4EGMNNPPM1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2185564-B1 Herbicidally active cyclopentanedione compounds and derivatives thereof SYNGENTA LTD (GB) 2014-06-18 EP disclosed
US-8754242-B2 Herbicides SYNGENTA CROP PROTECTION LLC (US) 2014-06-17 US disclosed
US-20120094832-A1 NOVEL HERBICIDES SYNGENTA LIMITED (GB) 2012-04-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120094832-A1 NOVEL HERBICIDES DDT, CYP1B1, CYP1A1 L3MBTL1 1525/4885TDP1 1362/4885KDM4E 1070/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.