Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.40 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18753660 | 0.85 | HTR4 (0.50) | NAMPTKMT2AALDH1A1ACHEHTR4 | |
| SCHEMBL20073407 | 0.83 | HPGD (0.47) | MEN1KMT2AALDH1A1LRRK2KDM4E | |
| SCHEMBL13880931 | 0.81 | HTR4 (0.52) | MEN1KMT2AALDH1A1KDM4EHTR4 | |
| SCHEMBL15650740 | 0.81 | HSP90AA1 (0.46) | PDE4APDE4BPDE4CPDE4DNAMPT | |
| SCHEMBL20750534 | 0.81 | KDM4E (0.44) | MEN1KMT2AALDH1A1LRRK2KDM4E | |
| SCHEMBL16982497 | 0.79 | KMT2A (0.53) | MEN1KMT2AALDH1A1LRRK2KDM4E | |
| SCHEMBL20750393 | 0.79 | KDM4E (0.40) | MEN1KMT2AALDH1A1KDM4EHTR4 | |
| SCHEMBL20750380 | 0.77 | SIGMAR1 (0.46) | KDM4ELMNAGLAHTTRAB9A | |
| SCHEMBL17076877 | 0.77 | LRRK2 (0.51) | KMT2ALRRK2KDM4EGLAPOLB | |
| SCHEMBL20036180 | 0.75 | NAMPT (0.60) | NAMPTKMT2APRKAA2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2704720-B1 | PYRUVATE KINASE R ACTIVATORS FOR USE IN THERAPY | AGIOS PHARMACEUTICALS INC (US) | 2019-08-07 | — | — | EP | disclosed |