Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 5/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 5/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16982522 | 0.88 | KMT2A (0.51) | KMT2AMEN1HPGDTSHRPOLB | |
| SCHEMBL20750534 | 0.88 | KDM4E (0.44) | KMT2AMEN1POLBLRRK2KDM4E | |
| SCHEMBL20073407 | 0.88 | HPGD (0.47) | KMT2AMEN1HPGDTSHRLRRK2 | |
| SCHEMBL17076877 | 0.85 | LRRK2 (0.51) | KMT2AHPGDPOLBLRRK2KDM4E | |
| SCHEMBL20750380 | 0.85 | SIGMAR1 (0.46) | HPGDKDM4ELMNAGLAHTT | |
| SCHEMBL520418 | 0.84 | POLB (0.63) | KMT2AMEN1HPGDTSHRPOLB | |
| SCHEMBL29531076 | 0.84 | POLB (0.63) | KMT2AMEN1HPGDTSHRPOLB | |
| SCHEMBL15650740 | 0.84 | HSP90AA1 (0.46) | KMT2AMEN1HPGDLRRK2KDM4E | |
| SCHEMBL4246868 | 0.82 | EPHX2 (0.54) | KMT2AMEN1HPGDTSHRPOLB | |
| SCHEMBL16982335 | 0.81 | L3MBTL1 (0.51) | KMT2AMEN1HPGDTSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3099694-B1 | COMPOUNDS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2019-01-16 | — | — | EP | disclosed |
| EP-3099694-B1 | COMPOUNDS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2019-01-16 | — | — | EP | disclosed |
| US-9815841-B2 | Compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-11-14 | — | — | US | disclosed |
| US-9815841-B2 | Compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-11-14 | — | — | US | disclosed |
| US-9815841-B2 | Compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-11-14 | — | — | US | disclosed |
| US-20170022204-A1 | COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-01-26 | — | — | US | disclosed |
| US-20170022204-A1 | COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-01-26 | — | — | US | disclosed |
| US-20170022204-A1 | COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-01-26 | — | — | US | disclosed |
| WO-2015113451-A1 | COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2015-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170022204-A1 | COMPOUNDS | LRRK2, PARK7, PINK1 | KMT2A 2719/4885MEN1 4512/4885HPGD 3255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.