Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Xylitol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adonitol SCHEMBL27558452 | 0.94 | LMNA (0.58) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Sorbitol SCHEMBL2122836 | 0.94 | LMNA (0.65) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL27645017 | 0.88 | LMNA (0.73) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL27515859 | 0.88 | LMNA (0.65) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Sorbitol SCHEMBL5801966 | 0.88 | LMNA (0.65) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Adonitol SCHEMBL27597842 | 0.86 | LMNA (0.70) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Adonitol SCHEMBL29012527 | 0.81 | LMNA (0.62) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Gluconic Acid SCHEMBL16026609 | 0.81 | LMNA (0.83) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Xylitol SCHEMBL5273838 | 0.80 | LMNA (0.83) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Xylitol SCHEMBL1924966 | 0.80 | LMNA (0.83) | LMNAL3MBTL1TDP1PDE4AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9375449-B2 | Metal ion nanoclusters | LG Bionano, LLC (US) | 2016-06-28 | — | — | US | disclosed |
| EP-2629758-A2 | METAL ION NANOCLUSTERS | LG Bionano, LLC (US) | 2013-08-28 | — | — | EP | disclosed |
| WO-2012054376-A2 | METAL ION NANOCLUSTERS | LG Bionano, LLC (US) | 2012-04-26 | — | — | WO | disclosed |
| US-20120093898-A1 | Metal Ion Nanoclusters | LG Bionano, LLC (US) | 2012-04-19 | — | — | US | disclosed |