Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mannitol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | PDE4A | P27815 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CA4 | P22748 | 3/20 | 0.36 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mannitol SCHEMBL27515859 | 0.94 | LMNA (0.65) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Sorbitol SCHEMBL5801966 | 0.94 | LMNA (0.65) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Sorbitol SCHEMBL2122836 | 0.94 | LMNA (0.65) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL27789598 | 0.92 | LMNA (0.77) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL15720563 | 0.89 | LMNA (0.67) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Sorbitol SCHEMBL31346584 | 0.89 | LMNA (0.67) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL15720393 | 0.89 | LMNA (0.67) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Xylitol SCHEMBL2123188 | 0.88 | LMNA (0.58) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Adonitol SCHEMBL27558452 | 0.88 | LMNA (0.58) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Gluconic Acid SCHEMBL28495557 | 0.88 | LMNA (0.95) | LMNAL3MBTL1TDP1PDE4AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1980669-A | New compositions containing quinoline compounds | ACTIVE BIOTECH AB (SE) | 2007-06-13 | — | — | CN | disclosed |
| CN-1771996-A | Effervescent pearl tablet and its prepn | SHANGHAI LEIYUNSHANG PHARMACEU (CN) | 2006-05-17 | — | — | CN | disclosed |
| CN-1762399-A | American ginseng effervescence tablet and its preparation method | SHANGHAI LEI YUN SHANG PHARMAC (CN) | 2006-04-26 | — | — | CN | disclosed |