Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sorbitol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | PDE4A | P27815 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | TOP1 | P11387 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mannitol SCHEMBL27515859 | 1.00 | LMNA (0.65) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL27645017 | 0.94 | LMNA (0.73) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Adonitol SCHEMBL27558452 | 0.94 | LMNA (0.58) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Sorbitol SCHEMBL2122836 | 0.94 | LMNA (0.65) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL27797259 | 0.90 | LMNA (0.56) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Xylitol SCHEMBL2123188 | 0.88 | LMNA (0.58) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Gluconic Acid SCHEMBL28437085 | 0.88 | LMNA (0.87) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Gluconic Acid SCHEMBL28860760 | 0.86 | PDE4A (0.83) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Gluconic Acid SCHEMBL27868062 | 0.86 | PDE4A (0.83) | LMNAL3MBTL1TDP1PDE4AUSP2 | |
| Mannitol SCHEMBL27789598 | 0.86 | LMNA (0.77) | LMNAL3MBTL1TDP1PDE4AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017100656-A1 | DRY POWDER FORMULATIONS OF ASPIRIN FOR INHALATION | OTITOPIC INC. (US) | 2017-06-15 | — | — | WO | disclosed |
| WO-2006082596-A2 | NEEM OIL CONTRACEPTIVE FORMULATIONS | SINGH KAMALINDER KAUR (IN) | 2006-08-10 | — | — | WO | disclosed |
| US-20060135613-A1 | Carboxamides derivatives | BAYER HEALTHCARE AG (DE) | 2006-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135613-A1 | Carboxamides derivatives | BPHL, HRH2, HRH4 | LMNA 1869/4885L3MBTL1 4574/4885TDP1 4168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.