Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.39 |
| ▸ | DRD3 | P35462 | 9/20 | 0.39 |
| ▸ | DRD4 | P21917 | 8/20 | 0.39 |
| ▸ | DRD1 | P21728 | 6/20 | 0.39 |
| ▸ | DRD5 | P21918 | 6/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | HTR5A | P47898 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2123810 | 0.84 | DRD2 (0.36) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL2123254 | 0.81 | DRD2 (0.38) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL4084257 | 0.81 | MTNR1B (0.50) | MTNR1B | |
| SCHEMBL2122590 | 0.78 | ESR1 (0.47) | MTNR1BABCB1ABCG2MAPTRAB9A | |
| SCHEMBL4082358 | 0.78 | MTNR1B (0.49) | DRD2DRD3MTNR1BHTR1D | |
| SCHEMBL2121978 | 0.76 | ABCB1 (0.39) | MTNR1BABCB1ABCG2MAPTRAB9A | |
| SCHEMBL4496501 | 0.76 | DRD2 (0.45) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL3949854 | 0.76 | DRD2 (0.45) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL2123807 | 0.74 | DRD2 (0.37) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL27669707 | 0.74 | DRD2 (0.44) | DRD2DRD3DRD4DRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2443110-A1 | S1P1 AGONISTS COMPRISING A BICYCLIC N-CONTAINING RING | Glaxo Group Limited (GB) | 2012-04-25 | — | — | EP | disclosed |
| EP-2443112-A1 | THIAZOLE OR THIADIZALOE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS | Glaxo Group Limited (GB) | 2012-04-25 | — | — | EP | disclosed |
| WO-2010146105-A1 | S1P1 AGONISTS COMPRISING A BICYCLIC N-CONTAINING RING | GLAXO GROUP LIMITED (GB) | 2010-12-23 | — | — | WO | disclosed |
| EP-2225233-A1 | OXADIAZOLE DERIVATIVES ACTIVE ON SPHINGOSINE-1-PHOSPHATE (S1P) | Glaxo Group Limited (GB) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009080724-A1 | OXADIAZOLE DERIVATIVES ACTIVE ON SPHINGOSINE-1-PHOSPHATE (S1P) | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |