Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.63 |
| ▸ | KIT | P10721 | 4/20 | 0.62 |
| ▸ | LCK | P06239 | 3/20 | 0.62 |
| ▸ | SRC | P12931 | 3/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.62 |
| ▸ | ABL1 | P00519 | 1/20 | 0.62 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.60 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.59 |
| ▸ | BRAF | P15056 | 2/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.54 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.53 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.53 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.53 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.53 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16881794 | 0.86 | NPC1 (0.75) | HDAC8HDAC6KITMAPK14BRAF | |
| SCHEMBL12201888 | 0.82 | HDAC8 (0.74) | HDAC8HDAC6NR1H4HDAC3NPC1 | |
| SCHEMBL19662798 | 0.81 | NT5E (0.70) | KITLCKSRCMAPK14ABL1 | |
| SCHEMBL21237370 | 0.79 | EGFR (0.61) | HDAC8HDAC6KITNR1H4BRAF | |
| SCHEMBL20064059 | 0.78 | KCNK3 (0.77) | HDAC8HDAC6NR1H4HDAC3RAB9A | |
| SCHEMBL8462152 | 0.78 | HDAC6 (0.77) | HDAC8HDAC6NR1H4HDAC3NPC1 | |
| SCHEMBL2565097 | 0.78 | KMT2A (0.76) | HDAC8HDAC6BRAFHDAC3NPC1 | |
| SCHEMBL19662757 | 0.78 | BCAT2 (0.66) | KITLCKSRCMAPK14ABL1 | |
| SCHEMBL2947918 | 0.77 | LCK (1.00) | KITLCKSRCMAPK14ABL1 | |
| SCHEMBL21237357 | 0.77 | BRAF (0.61) | HDAC6MAPK14BCAT2BRAFNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220127265-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2022-04-28 | — | — | US | disclosed |
| US-11247989-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2022-02-15 | — | — | US | disclosed |
| US-20190241558-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2019-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11247989-B2 | Therapeutic compounds and uses thereof | EP300, HDAC1, CREBBP | HDAC8 51/4885HDAC6 22/4885KIT 2588/4885 |
| US-20190241558-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | EP300, HDAC1, CREBBP | HDAC8 51/4885HDAC6 22/4885KIT 2588/4885 |
| US-20220127265-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | EP300, HDAC1, CREBBP | HDAC8 51/4885HDAC6 22/4885KIT 2588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.