Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.77 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.77 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | RXRA | P19793 | 1/20 | 0.57 |
| ▸ | RXRB | P28702 | 1/20 | 0.57 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.55 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12201888 | 0.89 | HDAC8 (0.74) | HDAC6HDAC8NR1H4KMT2AMEN1 | |
| SCHEMBL8458778 | 0.87 | HDAC8 (0.78) | HDAC6HDAC8NR1H4KMT2AMEN1 | |
| SCHEMBL8460187 | 0.86 | HDAC6 (0.75) | HDAC6HDAC8NR1H4KMT2AMEN1 | |
| SCHEMBL7297239 | 0.84 | NR1H4 (0.81) | HDAC6HDAC8NR1H4KMT2AMEN1 | |
| SCHEMBL3873116 | 0.84 | NR1H4 (0.81) | HDAC6HDAC8NR1H4KMT2AMEN1 | |
| SCHEMBL9067770 | 0.84 | KMT2A (1.00) | HDAC6HDAC8KMT2AMEN1KCNK9 | |
| SCHEMBL2058359 | 0.82 | KMT2A (0.96) | HDAC6HDAC8NR1H4KMT2AMEN1 | |
| SCHEMBL13561213 | 0.81 | KCNK9 (0.83) | HDAC6HDAC8NR1H4KMT2AMEN1 | |
| SCHEMBL14195814 | 0.81 | KCNK9 (0.83) | HDAC6HDAC8NR1H4KMT2AMEN1 | |
| SCHEMBL179538 | 0.81 | RXRA (0.66) | HDAC6HDAC8NR1H4RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999048529-A1 | RETINOID-GLITAZONE COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 1999-09-30 | — | — | WO | disclosed |
| EP-0808159-A1 | USE OR RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024344-A1 | USE OF RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1996-08-15 | — | — | WO | disclosed |
| US-5489611-A | ADMINISTERING A RETINOID COMPOUND | WARNER-LAMBERT COMPANY (US) | 1996-02-06 | — | — | US | disclosed |