Zd-6169

Zd-6169

SCHEMBL2123811

CC(O)(C(=O)Nc1ccc(C(=O)c2ccccc2)cc1)C(F)(F)F

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ABCC9 O60706 12/20 1.00
ABCC8 Q09428 12/20 1.00
KCNJ11 Q14654 12/20 1.00
KCNJ8 Q15842 12/20 1.00
PDK1 Q15118 9/20 1.00
PDK2 Q15119 9/20 1.00
PDK3 Q15120 9/20 1.00
PDK4 Q16654 9/20 1.00
ABCB11 O95342 1/20 1.00
MEN1 O00255 1/20 0.66
CYP1A2 P05177 1/20 0.66
CYP3A4 P08684 1/20 0.66
CYP2D6 P10635 1/20 0.66
TSHR P16473 1/20 0.66
CYP2C19 P33261 1/20 0.66
KMT2A Q03164 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Zd-6169 SCHEMBL4261046 1.00 ABCC9 (1.00) ABCC9ABCC8KCNJ11KCNJ8PDK1
SCHEMBL8866509 0.88 ABCC9 (1.00) ABCC9ABCC8KCNJ11KCNJ8PDK1
SCHEMBL28050469 0.87 PDK1 (1.00) ABCC9ABCC8KCNJ11KCNJ8PDK1
SCHEMBL6359557 0.87 PDK1 (1.00) ABCC9ABCC8KCNJ11KCNJ8PDK1
SCHEMBL8865996 0.86 ABCC9 (1.00) ABCC9ABCC8KCNJ11KCNJ8PDK1
SCHEMBL5317709 0.86 PDK1 (0.75) ABCC9ABCC8KCNJ11KCNJ8PDK1
SCHEMBL8866169 0.85 ABCC9 (0.74) ABCC9ABCC8KCNJ11KCNJ8PDK1
SCHEMBL8866495 0.85 ABCC9 (1.00) ABCC9ABCC8KCNJ11KCNJ8PDK1
SCHEMBL8866235 0.84 ABCC9 (0.73) ABCC9ABCC8KCNJ11KCNJ8PDK1
SCHEMBL8866390 0.83 ABCC9 (0.70) ABCC9ABCC8KCNJ11KCNJ8PDK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004056181-A1 ORGAN PRECONDITIONING, ARREST, PROTECTION, PRESERVATION AND RECOVERY (2) GLOBAL CARDIAC SOLUTIONS PTY LTD (AU) 2004-07-08 WO claimed
WO-2004056180-A1 ORGAN PRECONDITIONING, ARREST, PROTECTION, PRESERVATION AND RECOVERY (1) GLOBAL CARDIAC SOLUTIONS PTY LTD (AU) 2004-07-08 WO claimed
US-5684198-A N-ARYL-2-HYDROXYPROPANAMIDES IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) 1997-11-04 US claimed
EP-0524781-B1 Therapeutic amides ZENECA LTD (GB) 1996-03-27 EP claimed
US-5382598-A Therapeutic amides IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1995-01-17 US claimed
EP-0524781-A1 Therapeutic amides ZENECA LIMITED (GB) 1993-01-27 EP claimed
US-20220265282-A1 USE OF REMOTE ISCHEMIC CONDITIONING FOR TRAUMATIC INJURY THE HOSPITAL FOR SICK CHILDREN (CA) 2022-08-25 US disclosed
US-11045207-B2 Use of remote ischemic conditioning for traumatic injury THE HOSPITAL FOR SICK CHILDREN (CA) 2021-06-29 US disclosed
WO-2021052952-A1 METHODS OF TREATMENT AND/OR PREVENTION OF DISORDERS AND SYMPTOMS RELATED TO BKCA AND/OR SK CHANNELOPHATHIES Universite de Bordeaux (FR) 2021-03-25 WO disclosed
EP-3791873-A1 METHODS OF TREATMENT AND/OR PREVENTION OF DISORDERS AND SYMPTOMS RELATED TO BKCA AND/OR SK CHANNELOPHATHIES UNIVERSITE DE BORDEAUX (FR) 2021-03-17 EP disclosed
EP-2723336-B1 COMPOSITIONS FOR THE TREATMENT OF FRAGILE X SYNDROME CENTRE NAT RECH SCIENT (FR) 2020-04-08 EP disclosed
US-10435366-B2 Compositions for the treatment of Fragile X syndrome CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2019-10-08 US disclosed
US-20190192169-A1 USE OF REMOTE ISCHEMIC CONDITIONING FOR TRAUMATIC INJURY THE HOSPITAL FOR SICK CHILDREN (CA) 2019-06-27 US disclosed
US-5565477-A TREATMENT OF URINARY INCONTINENCE IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1996-10-15 US disclosed
US-5565465-A TREATMENT OF URINARY INCONTINENCE IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1996-10-15 US disclosed
EP-0524781-B1 Therapeutic amides ZENECA LTD (GB) 1996-03-27 EP disclosed
US-5474999-A Useful in treatment of urinary incontinence IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1995-12-12 US disclosed
US-5382598-A Therapeutic amides IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1995-01-17 US disclosed
US-5272163-A Therapeutic amides IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-12-21 US disclosed
EP-0524781-A1 Therapeutic amides ZENECA LIMITED (GB) 1993-01-27 EP disclosed