Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.56 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2665689 | 0.81 | TDP1 (0.63) | KDM4EALDH1A1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL21186386 | 0.77 | CYP2D6 (0.63) | ALDH1A1SMN1; SMN2TDP1NPC1RAB9A | |
| SCHEMBL20311508 | 0.77 | ALDH1A1 (0.63) | KDM4EALDH1A1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL1680928 | 0.77 | SMN1; SMN2 (0.61) | KDM4EALDH1A1SMN1; SMN2TDP1NPC1 | |
| SCHEMBL1838892 | 0.77 | KDM4E (0.48) | KDM4EALDH1A1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL7456577 | 0.76 | KDM4E (0.64) | KDM4EALDH1A1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL18062419 | 0.76 | NPC1 (0.66) | KDM4EALDH1A1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL28327199 | 0.76 | NPC1 (0.66) | KDM4EALDH1A1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL507242 | 0.76 | RAB9A (0.66) | KDM4EALDH1A1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL1192767 | 0.75 | TDP1 (0.58) | KDM4EALDH1A1SMN1; SMN2TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968316-B1 | 2-HYDROXY-1-{4-[(4-PHENYLPHENYL)CARBONYL]PIPERAZIN-1-YL}ETHAN-1-ONE DERIVATIVES AND RELATED COMPOUNDS AS FATTY ACID SYNTHASE (FASN) INHIBITORS FOR THE TREATMENT OF CANCER | FORMA THERAPEUTICS INC (US) | 2019-08-07 | — | — | EP | disclosed |