Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.62 |
| ▸ | NPC1 | O15118 | 9/20 | 0.62 |
| ▸ | MAPT | P10636 | 10/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.52 |
| ▸ | RELA | Q04206 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 12/20 | 0.52 |
| ▸ | MEN1 | O00255 | 11/20 | 0.52 |
| ▸ | CLK1 | P49759 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22971623 | 0.93 | RAB9A (0.52) | RAB9ASMN1; SMN2NPC1MAPTALDH1A1 | |
| SCHEMBL21241927 | 0.90 | RAB9A (0.66) | RAB9ASMN1; SMN2NPC1MAPTALDH1A1 | |
| SCHEMBL22971633 | 0.80 | ALOX5 (0.55) | SMN1; SMN2MAPTALDH1A1LMNAKMT2A | |
| SCHEMBL21241928 | 0.79 | SCD (0.60) | MAPTALDH1A1KMT2AMEN1GAA | |
| SCHEMBL22971678 | 0.78 | HDAC3 (0.49) | RAB9ANPC1KMT2AMEN1POLB | |
| SCHEMBL16603987 | 0.78 | SMN1; SMN2 (0.79) | RAB9ASMN1; SMN2NPC1MAPTALDH1A1 | |
| SCHEMBL22971686 | 0.78 | MEN1 (0.45) | RAB9ASMN1; SMN2NPC1MAPTALDH1A1 | |
| SCHEMBL22971654 | 0.77 | ABL1 (0.55) | MAPTROCK2 | |
| SCHEMBL22971635 | 0.77 | ROCK1 (0.56) | MAPTALDH1A1ROCK2 | |
| SCHEMBL22971563 | 0.77 | ROCK1 (0.55) | MAPTALDH1A1KMT2AMEN1CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230138480-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2023-05-04 | — | — | US | disclosed |
| US-20230138480-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2023-05-04 | — | — | US | disclosed |
| US-20210038611-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2021-02-11 | — | — | US | disclosed |
| WO-2019152437-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2019-08-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230138480-A1 | COMPOUNDS AND USES THEREOF | VHL, CLN6, TFEB | RAB9A 572/4885SMN1; SMN2 40/4885NPC1 138/4885 |
| US-20210038611-A1 | COMPOUNDS AND USES THEREOF | VHL, CLN6, TFEB | RAB9A 572/4885SMN1; SMN2 40/4885NPC1 138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.