⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2520806 | 1.00 | — | — | |
| SCHEMBL23033142 | 1.00 | — | — | |
| SCHEMBL12162660 | 0.78 | — | — | |
| SCHEMBL29634723 | 0.76 | — | — | |
| SCHEMBL25053929 | 0.76 | — | — | |
| SCHEMBL9684760 | 0.76 | KMT2A (0.34) | — | |
| SCHEMBL28137306 | 0.75 | CHRNB2 (0.41) | — | |
| SCHEMBL28152363 | 0.75 | CHRNB2 (0.41) | — | |
| SCHEMBL28151260 | 0.75 | CHRNB2 (0.41) | — | |
| SCHEMBL29567784 | 0.74 | KMT2A (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024044713-A1 | NAPHTHYRIDINE COMPOUNDS FOR INHIBITION OF RAF KINASES | ENLIVEN INC. (US) | 2024-02-29 | — | — | WO | disclosed |
| WO-2022236319-A1 | NAPHTHYRIDONE COMPOUNDS FOR INHIBITION OF RAF KINASES AND/OR BCR-ABL TYROSINE KINASES | ENLIVEN THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |
| WO-2022236319-A1 | NAPHTHYRIDONE COMPOUNDS FOR INHIBITION OF RAF KINASES AND/OR BCR-ABL TYROSINE KINASES | ENLIVEN THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |
| WO-2019149244-A1 | JAK INHIBITOR AND USE THEREOF | 南京明德新药研发股份有限公司 | 2019-08-08 | — | — | WO | disclosed |