Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | ATAD2 | Q6PL18 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAP2 | P11137 | 1/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31639180 | 0.84 | PDPK1 (0.41) | BRD4KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL17362522 | 0.82 | MAP2K1 (0.40) | KDM4EGAAHPGDHSD17B10GRIN2D | |
| SCHEMBL21242333 | 0.82 | HSD17B10 (0.34) | BRD4KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL17883332 | 0.78 | ALDH1A1 (0.38) | BRD4PDPK1MAPTMAP2ALDH1A1 | |
| SCHEMBL31502285 | 0.71 | CAPN1 (0.46) | BRD4PDPK1MAPTMAP2JAK2 | |
| SCHEMBL30317842 | 0.71 | SLC9A1 (0.36) | BRD4PDPK1MAP2CCNCCDK8 | |
| SCHEMBL17178597 | 0.69 | GRIN2D (0.42) | BRD4KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL15478582 | 0.67 | HSD17B10 (0.56) | BRD4KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL31502297 | 0.67 | KDM4E (0.43) | BRD4KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL21543996 | 0.65 | ALDH1A1 (0.59) | KDM4EGAAMAPTALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3521289-A1 | MNK INHIBITORS AND METHODS RELATED THERETO | Effector Therapeutics Inc. (US) | 2019-08-07 | — | — | EP | disclosed |