Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | MAP2 | P11137 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | DPYD | Q12882 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | DDO | Q99489 | 1/20 | 0.31 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.31 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21242644 | 0.82 | BRD4 (0.37) | HSD17B10KDM4EGAAHPGDGRIN2D | |
| SCHEMBL31639180 | 0.79 | PDPK1 (0.41) | HSD17B10KDM4EGAAHPGDGRIN2D | |
| SCHEMBL17362522 | 0.78 | MAP2K1 (0.40) | HSD17B10KDM4EGAAHPGDGRIN2D | |
| SCHEMBL17883332 | 0.74 | ALDH1A1 (0.38) | PDPK1MAP2MAPTALDH1A1BRD4 | |
| SCHEMBL12946182 | 0.71 | HSD17B10 (0.50) | HSD17B10KDM4EGAAHPGDGRIN2D | |
| SCHEMBL11865775 | 0.67 | PDPK1 (0.41) | PDPK1MAP2 | |
| SCHEMBL31502285 | 0.67 | CAPN1 (0.46) | PDPK1MAP2MAPTBRD4 | |
| SCHEMBL30317842 | 0.67 | SLC9A1 (0.36) | PDPK1MAP2BRD4 | |
| SCHEMBL2222259 | 0.66 | SIRT3 (0.39) | KDM4EGAAALDH1A1BRD4POLB | |
| SCHEMBL5862445 | 0.65 | DPYD (0.39) | HSD17B10KDM4EGAAHPGDGRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020155842-A1 | POLYCYCLIC COMPOUND INHIBITING MNK1 AND MNK2 | 诺沃斯达药业有限公司 | 2020-08-06 | — | — | WO | disclosed |
| EP-3521289-A1 | MNK INHIBITORS AND METHODS RELATED THERETO | Effector Therapeutics Inc. (US) | 2019-08-07 | — | — | EP | disclosed |