Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.76 |
| ▸ | BAZ2B | Q9UIF8 | 2/20 | 0.76 |
| ▸ | LMNA | P02545 | 1/20 | 0.76 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | CASP1 | P29466 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.59 |
| ▸ | CASP7 | P55210 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17040277 | 0.89 | GPX4 (0.67) | MAPTBAZ2BLMNAKDM4EGPX4 | |
| SCHEMBL28387618 | 0.86 | BAZ2B (1.00) | MAPTBAZ2BLMNATAAR1KMT2A | |
| SCHEMBL28468258 | 0.85 | MAPT (0.77) | MAPTBAZ2BLMNATAAR1KMT2A | |
| SCHEMBL16462808 | 0.83 | MAPT (0.75) | MAPTBAZ2BLMNATAAR1KMT2A | |
| SCHEMBL14015615 | 0.83 | MAPT (0.75) | MAPTBAZ2BLMNATAAR1KMT2A | |
| SCHEMBL24405315 | 0.83 | MAPT (0.74) | MAPTBAZ2BLMNATAAR1KMT2A | |
| SCHEMBL17040355 | 0.81 | BAZ2B (0.51) | MAPTBAZ2BLMNATAAR1KMT2A | |
| SCHEMBL21222687 | 0.81 | TAAR1 (0.72) | MAPTBAZ2BLMNATAAR1KMT2A | |
| SCHEMBL3079170 | 0.81 | MAPT (0.71) | MAPTBAZ2BLMNATAAR1KMT2A | |
| SCHEMBL31228651 | 0.81 | TAAR1 (0.72) | MAPTBAZ2BLMNATAAR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210155625-A1 | 2,3,4,5-TETRAHYDRO-1H-PYRIDO[4, 3-b]INDOLE INHIBITORS OF cGAS FOR TREATING AUTOINFLAMMATORY DISEASES | THE ROCKEFELLER UNIVERSITY (US) | 2021-05-27 | — | — | US | disclosed |
| WO-2019153002-A1 | 2,3,4,5-TETRAHYDRO-1H-PYRIDO[4, 3-B]INDOLE INHIBITORS OF CGAS FOR TREATING AUTOINFLAMMATORY DISEASES | LAMA LODOE (US) | 2019-08-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210155625-A1 | 2,3,4,5-TETRAHYDRO-1H-PYRIDO[4, 3-b]INDOLE INHIBITORS OF cGAS FOR TREATING AUTOINFLAMMATORY DISEASES | STING1, IRF3, CGAS | MAPT 4371/4885BAZ2B 3306/4885LMNA 3393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.