Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.71 |
| ▸ | CFTR | P13569 | 3/20 | 0.70 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.65 |
| ▸ | CDK4 | P11802 | 6/20 | 0.62 |
| ▸ | CCND1 | P24385 | 6/20 | 0.62 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | CASP1 | P29466 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6492381 | 0.90 | CDK4 (0.63) | MAPTLMNABAZ2BCFTRMTHFD2 | |
| SCHEMBL12868422 | 0.90 | CDK4 (0.77) | MAPTLMNABAZ2BCFTRMTHFD2 | |
| SCHEMBL6335099 | 0.89 | CDK4 (0.76) | CDK4CCND1 | |
| SCHEMBL28468258 | 0.87 | MAPT (0.77) | MAPTLMNABAZ2BCFTRTAAR1 | |
| SCHEMBL3094630 | 0.87 | BAZ2B (0.61) | MAPTLMNABAZ2BCFTRCDK4 | |
| SCHEMBL12868451 | 0.86 | FAAH (0.61) | MAPTLMNABAZ2BCFTRMTHFD2 | |
| SCHEMBL19965770 | 0.86 | SIGMAR1 (0.56) | MAPTLMNABAZ2BCFTRMTHFD2 | |
| SCHEMBL31117575 | 0.85 | TRPV1 (0.68) | MAPTLMNABAZ2BCFTRCDK4 | |
| SCHEMBL31117415 | 0.85 | BAZ2B (0.72) | MAPTLMNABAZ2BCFTRCDK4 | |
| SCHEMBL11844405 | 0.84 | MTHFD2 (0.88) | MAPTLMNABAZ2BCFTRMTHFD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100234396-A1 | Tetrhydropyridoindole Derivatives | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-16 | — | — | US | disclosed |
| US-7714132-B2 | Tetrahydropyridoindole derivatives | ACTELION PHARMACEUTICALS, LTD. (CH) | 2010-05-11 | — | — | US | disclosed |
| US-20070191416-A1 | Tetrahydropyridoindole derivatives | IDORSIA PHARMACEUTICALS LTD (CH) | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234396-A1 | Tetrhydropyridoindole Derivatives | TPH2, TPH1, HTR5A | MAPT 375/4885LMNA 3190/4885BAZ2B 2653/4885 |
| US-20070191416-A1 | Tetrahydropyridoindole derivatives | TPH2, TPH1, HTR2C | MAPT 155/4885LMNA 3204/4885BAZ2B 2859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.