Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | NPY1R | P25929 | 1/20 | 0.55 |
| ▸ | LTA4H | P09960 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26024996 | 0.83 | MEN1 (0.50) | HTTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL12869921 | 0.81 | EGFR (0.60) | HTTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL165769 | 0.80 | KMT2A (0.54) | SMN1; SMN2ALDH1A1KMT2AMEN1MAPK1 | |
| SCHEMBL11128528 | 0.79 | EGFR (0.58) | HTTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL167209 | 0.79 | KMT2A (0.51) | SMN1; SMN2ALDH1A1KMT2AMEN1MAPK1 | |
| SCHEMBL6621341 | 0.78 | SMN1; SMN2 (0.59) | HTTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL6393260 | 0.78 | LTA4H (0.84) | HTTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL20981242 | 0.78 | HTT (0.71) | HTTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5396713 | 0.78 | LTA4H (0.53) | HTTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL20228004 | 0.78 | DRD2 (0.58) | HTTNPC1RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019149965-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PAIN | UNIVERSITE DE STRASBOURG (FR) | 2019-08-08 | — | — | WO | disclosed |