Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.48 |
| ▸ | DRD3 | P35462 | 9/20 | 0.48 |
| ▸ | DRD4 | P21917 | 7/20 | 0.48 |
| ▸ | DRD1 | P21728 | 5/20 | 0.48 |
| ▸ | DRD5 | P21918 | 5/20 | 0.48 |
| ▸ | HTR5A | P47898 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2123807 | 0.88 | DRD2 (0.37) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL2124394 | 0.83 | DRD2 (0.47) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL5777461 | 0.81 | DRD2 (0.49) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL2123989 | 0.81 | SLC6A2 (0.36) | DRD2 | |
| SCHEMBL2121244 | 0.80 | ESR1 (0.40) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL3430802 | 0.77 | DRD2 (0.36) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL2123452 | 0.76 | NOTUM (0.43) | DRD2 | |
| SCHEMBL2122364 | 0.73 | ESR1 (0.39) | — | |
| SCHEMBL506250 | 0.72 | DRD2 (0.47) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL2123005 | 0.72 | NOTUM (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2443110-A1 | S1P1 AGONISTS COMPRISING A BICYCLIC N-CONTAINING RING | Glaxo Group Limited (GB) | 2012-04-25 | — | — | EP | disclosed |
| WO-2010146105-A1 | S1P1 AGONISTS COMPRISING A BICYCLIC N-CONTAINING RING | GLAXO GROUP LIMITED (GB) | 2010-12-23 | — | — | WO | disclosed |
| EP-2222669-A1 | OXADIAZOLE DERIVATIVES ACTIVE ON SPHINGOSINE-1-PHOSPHATE (SIP) | Glaxo Group Limited (GB) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009080725-A1 | OXADIAZOLE DERIVATIVES ACTIVE ON SPHINGOSINE-1-PHOSPHATE (SIP) | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |