Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.54 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.54 |
| ▸ | MCOLN1 | Q9GZU1 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21244028 | 0.94 | MCOLN3 (0.60) | ALDH1A1MCOLN3MCOLN2MCOLN1KMT2A | |
| SCHEMBL7672822 | 0.90 | MCOLN3 (0.62) | ALDH1A1MCOLN3MCOLN2MCOLN1KMT2A | |
| SCHEMBL21244025 | 0.86 | GAA (0.71) | ALDH1A1MCOLN3MCOLN2MCOLN1KMT2A | |
| SCHEMBL21244030 | 0.84 | MAPT (0.55) | ALDH1A1MCOLN3MCOLN2MCOLN1KMT2A | |
| SCHEMBL23043588 | 0.82 | MCOLN3 (0.76) | ALDH1A1MCOLN3MCOLN2MCOLN1KMT2A | |
| SCHEMBL29978509 | 0.82 | MCOLN3 (0.76) | ALDH1A1MCOLN3MCOLN2MCOLN1KMT2A | |
| SCHEMBL23043775 | 0.82 | MCOLN3 (0.76) | ALDH1A1MCOLN3MCOLN2MCOLN1KMT2A | |
| SCHEMBL29978305 | 0.82 | MCOLN3 (0.76) | ALDH1A1MCOLN3MCOLN2MCOLN1KMT2A | |
| SCHEMBL5558969 | 0.80 | MCOLN3 (0.57) | ALDH1A1MCOLN3MCOLN2MCOLN1KMT2A | |
| SCHEMBL21261289 | 0.79 | MAPT (0.58) | ALDH1A1MAPTRECQLUSP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10851084-B2 | Piperazine derivatives as TRPML modulators | Lysoway Therapeutics, Inc. (US) | 2020-12-01 | — | — | US | claimed |
| US-20190248764-A1 | PIPERAZINE DERIVATIVES AS TRPML MODULATORS | CalyGene Biotechnolgy, Inc. (US) | 2019-08-15 | — | — | US | claimed |
| US-10851084-B2 | Piperazine derivatives as TRPML modulators | Lysoway Therapeutics, Inc. (US) | 2020-12-01 | — | — | US | disclosed |
| US-10851084-B2 | Piperazine derivatives as TRPML modulators | Lysoway Therapeutics, Inc. (US) | 2020-12-01 | — | — | US | disclosed |
| US-20190248764-A1 | PIPERAZINE DERIVATIVES AS TRPML MODULATORS | CalyGene Biotechnolgy, Inc. (US) | 2019-08-15 | — | — | US | disclosed |
| US-20190248764-A1 | PIPERAZINE DERIVATIVES AS TRPML MODULATORS | CalyGene Biotechnolgy, Inc. (US) | 2019-08-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10851084-B2 | Piperazine derivatives as TRPML modulators | TRPM5, TRPM2, TRPM4 | ALDH1A1 2820/4885MCOLN3 9/4885MCOLN2 8/4885 |
| US-20190248764-A1 | PIPERAZINE DERIVATIVES AS TRPML MODULATORS | TRPM5, TRPM2, TRPM4 | ALDH1A1 2820/4885MCOLN3 9/4885MCOLN2 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.