Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2123754 | 0.80 | FGFR1 (0.35) | CXCR4TSHRKMT2AACHEPTGS2 | |
| SCHEMBL369262 | 0.75 | TSHR (0.45) | CXCR4L3MBTL1TSHRKMT2AMEN1 | |
| SCHEMBL2123473 | 0.73 | KMT2A (0.58) | CXCR4L3MBTL1TSHRKMT2AMEN1 | |
| SCHEMBL6284422 | 0.72 | L3MBTL1 (0.43) | L3MBTL1NPC1RAB9AACHEPTGS2 | |
| SCHEMBL1206400 | 0.72 | CXCR4 (0.48) | CXCR4L3MBTL1TSHRKMT2AMEN1 | |
| SCHEMBL1205392 | 0.69 | CXCR4 (0.53) | CXCR4L3MBTL1KMT2AMEN1NPC1 | |
| SCHEMBL2046392 | 0.69 | HRH3 (0.48) | TSHRNPC1RAB9AACHEPTGS2 | |
| SCHEMBL13002587 | 0.69 | MAPK1 (0.43) | CXCR4TSHRKMT2AMEN1NPC1 | |
| SCHEMBL12087626 | 0.69 | TSHR (0.43) | CXCR4L3MBTL1TSHRKMT2AMEN1 | |
| SCHEMBL1638006 | 0.69 | CXCR4 (0.60) | CXCR4L3MBTL1TSHRKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476290-B2 | Compound having spiro-bonded cyclic group and use thereof | ONO PHARMACEUTICAL CO., LTD. (JP) | 2013-07-02 | — | — | US | disclosed |
| US-20120101280-A1 | COMPOUND HAVING SPIRO-BONDED CYCLIC GROUP AND USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2012-04-26 | — | — | US | disclosed |
| EP-2444402-A1 | COMPOUND HAVING SPIRO-BONDED CYCLIC GROUP AND USE THEREOF | ONO Pharmaceutical Co., Ltd. (JP) | 2012-04-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101280-A1 | COMPOUND HAVING SPIRO-BONDED CYCLIC GROUP AND USE THEREOF | CXCR4, CXCL12, CCR5 | CXCR4 1/4885L3MBTL1 1607/4885TSHR 2200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.