Sugi Predict

Sugi Predict / Compounds / SCHEMBL2124530

SCHEMBL2124530

SCHEMBL2124530

CCOC(=O)C(=O)c1ccc(C(C)C)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 4/20 0.48
▸ SMN1; SMN2 Q16637 4/20 0.48
▸ HTT P42858 2/20 0.48
▸ ALDH1A1 P00352 3/20 0.47
▸ MAPT P10636 1/20 0.47
▸ USP5 P45974 1/20 0.46
▸ CYP1A2 P05177 1/20 0.44
▸ CYP3A4 P08684 1/20 0.44
▸ MAOA P21397 1/20 0.44
▸ L3MBTL1 Q9Y468 3/20 0.43
▸ CYP2C9 P11712 1/20 0.43
▸ RXRA P19793 1/20 0.43
▸ RXRB P28702 1/20 0.43
▸ NPC1 O15118 3/20 0.43
▸ RAB9A P51151 3/20 0.43
▸ HPGD P15428 1/20 0.42
▸ CA12 O43570 1/20 0.42
▸ CA1 P00915 1/20 0.42
▸ CA2 P00918 1/20 0.42
▸ ESR1 P03372 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21636225 0.87 MAPT (0.49) LMNAHTTALDH1A1MAPTCYP1A2
SCHEMBL21065593 0.83 LMNA (0.46) LMNASMN1; SMN2HTTALDH1A1MAPT
SCHEMBL570567 0.81 LMNA (0.67) LMNASMN1; SMN2HTTALDH1A1MAPT
SCHEMBL1408429 0.81 LMNA (0.67) LMNASMN1; SMN2HTTALDH1A1MAPT
SCHEMBL1525403 0.81 CES2 (0.57) LMNASMN1; SMN2HTTALDH1A1MAPT
SCHEMBL167161 0.81 CES2 (0.60) LMNASMN1; SMN2HTTALDH1A1MAPT
SCHEMBL21636244 0.81 MAPT (0.53) LMNASMN1; SMN2HTTALDH1A1MAPT
SCHEMBL8375080 0.80 LMNA (0.43) LMNASMN1; SMN2HTTALDH1A1MAPT
SCHEMBL8375083 0.80 LMNA (0.43) LMNASMN1; SMN2HTTALDH1A1MAPT
SCHEMBL4688947 0.80 SMN1; SMN2 (0.53) LMNASMN1; SMN2HTTALDH1A1USP5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111170991-B Antiproliferative compounds and methods of synthesis thereof 细胞基因公司 2023-10-31 — — CN disclosed
EP-3594211-B1 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF CELGENE CORP (US) 2023-10-25 — — EP disclosed
US-20220387413-A1 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF CELGENE CORP (US) 2022-12-08 — — US disclosed
US-11241423-B2 Antiproliferative compounds and methods of use thereof CELGENE CORPORATION (US) 2022-02-08 — — US disclosed
US-20200163948-A1 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF CELGENE CORP (US) 2020-05-28 — — US disclosed
CN-111170991-A Antiproliferative compounds and methods of synthesis thereof 细胞基因公司 2020-05-19 — — CN disclosed
CN-106660991-B Antiproliferative compounds and methods of use thereof 细胞基因公司 2020-03-13 — — CN disclosed
EP-3166937-B1 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF CELGENE CORP (US) 2019-09-04 — — EP disclosed
US-20180221361-A1 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF CELGENE CORP (US) 2018-08-09 — — US disclosed
US-9968596-B2 Antiproliferative compounds and methods of use thereof CELGENE CORPORATION (US) 2018-05-15 — — US disclosed
US-4157449-A Ethynylbenzene compounds and derivatives thereof WILLIAM H. RORER, INC. (US) 1979-06-05 — — US disclosed
US-4120889-A Cyano ethynylbenzene compounds WILLIAM H. RORER, INC. (US) 1978-10-17 — — US disclosed
US-4120885-A Ethynylbenzene compounds and derivatives thereof WILLIAM H. RORER, INC. (US) 1978-10-17 — — US disclosed
US-4105786-A ANTIINFLAMMATORY WILLIAM H. RORER, INC. (US) 1978-08-08 — — US disclosed
US-4101591-A Ethynylbenzene compounds and derivatives thereof WILLIAM H. RORER, INC. (US) 1978-07-18 — — US disclosed
US-4096279-A Ethynylbenzene compounds and derivatives thereof in the treatment of pain fever and inflammation WILLIAM H. RORER, INC. (US) 1978-06-20 — — US disclosed
US-4094995-A ETHYNYLBENZENE COMPOUNDS AND DERIVATIVES THEREOF TO TREAT PAIN, FEVER AND INFLAMMATION WILLIAM H. RORER, INC. (US) 1978-06-13 — — US disclosed
US-4093737-A Ethynylbenzene compounds and derivatives thereof in the treatment of pain, fever or inflammation WILLIAM H. RORER, INC. (US) 1978-06-06 — — US disclosed
US-4075354-A ETHYNYLBENZENE COMPOUNDS AND DERIVATIVES THEREOF FOR TREATING PAIN FEVER AND INFLAMMATION WILLIAM H. RORER, INC. (US) 1978-02-21 — — US disclosed
US-3981932-A Ethynylbenzene compounds and derivatives thereof WILLIAM H. RORER, INC. (US) 1976-09-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220387413-A1 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF MCL1, MKI67, BAX LMNA 998/4885SMN1; SMN2 289/4885HTT 2914/4885
US-11241423-B2 Antiproliferative compounds and methods of use thereof MCL1, MKI67, BAX LMNA 998/4885SMN1; SMN2 289/4885HTT 2914/4885
US-20200163948-A1 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF MCL1, MKI67, BAX LMNA 998/4885SMN1; SMN2 289/4885HTT 2914/4885
US-20180221361-A1 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF MCL1, MKI67, BAX LMNA 998/4885SMN1; SMN2 289/4885HTT 2914/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.