Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 3/20 | 0.60 |
| ▸ | CES1 | P23141 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | DHODH | Q02127 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11839592 | 0.94 | CES2 (0.54) | CES2CES1ALDH1A1MAPTGAA | |
| SCHEMBL20326025 | 0.91 | MMP13 (0.53) | CES2CES1ALDH1A1MAPTGAA | |
| SCHEMBL21636244 | 0.88 | MAPT (0.53) | CES2CES1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL641616 | 0.86 | CA12 (0.66) | CES2ALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL166220 | 0.84 | MAPT (0.57) | CES2CES1ALDH1A1MAPTGAA | |
| SCHEMBL13909369 | 0.84 | ALDH1A1 (0.50) | CES2CES1ALDH1A1MAPTHTT | |
| SCHEMBL9041402 | 0.84 | MAPT (0.50) | CES2CES1ALDH1A1MAPTGAA | |
| SCHEMBL21636242 | 0.84 | KMT2A (0.50) | CES2CES1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL1408429 | 0.84 | LMNA (0.67) | ALDH1A1MAPTGAASMN1; SMN2HTT | |
| SCHEMBL696315 | 0.84 | KMT2A (0.57) | CES2CES1ALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 92 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3619214-B1 | GAMMA-SPIROKETAL-GAMMA-LACTONES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AND PROCESS FOR PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2024-11-06 | — | — | EP | claimed |
| US-11339174-B2 | γ-spiroketal-γ-lactones and pharmaceutical composition containing same and process for preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2022-05-24 | — | — | US | claimed |
| US-20210198273-A1 | GAMMA-SPIROKETAL-GAMMA-LACTONES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AND PROCESS FOR PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2021-07-01 | — | — | US | claimed |
| EP-3619214-A1 | GAMMA-SPIROKETAL-GAMMA-LACTONES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AND PROCESS FOR PREPARATION THEREOF | Council of Scientific and Industrial Research (IN) | 2020-03-11 | — | — | EP | claimed |
| WO-2018203346-A1 | γ-SPIROKETAL- γ –LACTONES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AND PROCESS FOR PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2018-11-08 | — | — | WO | claimed |
| US-20260070874-A1 | BENZOYLFORMIC ACID AMIDE DERIVATIVE | KJ CHEMICALS CORPORATION (JP) | 2026-03-12 | — | — | US | disclosed |
| US-12516065-B2 | Tertiary alcohols as PI3K-γ inhibitors | INCYTE CORPORATION (US) | 2026-01-06 | — | — | US | disclosed |
| EP-4610249-A1 | BENZOYLFORMIC ACID AMIDE DERIVATIVE | KJ Chemicals Corporation (JP) | 2025-09-03 | — | — | EP | disclosed |
| EP-3619214-B1 | GAMMA-SPIROKETAL-GAMMA-LACTONES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AND PROCESS FOR PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2024-11-06 | — | — | EP | disclosed |
| WO-2024210074-A1 | BENZOYLFORMIC ACID AMIDE DERIVATIVE | ＫＪケミカルズ株式会社 | 2024-10-10 | — | — | WO | disclosed |
| US-20240228498-A1 | TERTIARY ALCOHOLS AS PI3K-y INHIBITORS | INCYTE CORPORATION | 2024-07-11 | — | — | US | disclosed |
| CN-118063470-A | Condensed imidazole derivatives substituted with tertiary hydroxyl groups as PI 3K-gamma inhibitors | 因赛特公司 | 2024-05-24 | — | — | CN | disclosed |
| US-6329547-B1 | USEFUL AS THERAPEUTIC AGENTS FOR GLAUCOMA | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2001-12-11 | — | — | US | disclosed |
| EP-1094055-A1 | NOVEL VINYLBENZENE DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2001-04-25 | — | — | EP | disclosed |
| EP-0701551-B1 | 3-(INDOL-3-YL) PROPENOIC ACID DERIVATIVES USEFUL AS NMDA ANTAGONISTS | MERRELL PHARMA INC (US) | 1997-04-16 | — | — | EP | disclosed |
| US-5519048-A | 3-(indol-3-yl)-propenoic acid derivatives and pharmaceutical compositions thereof | MERRELL PHARMACEUTICALS INC. (US) | 1996-05-21 | — | — | US | disclosed |
| EP-0701551-A1 | 3-(INDOL-3-YL) PROPENOIC ACID DERIVATIVES AND AS NMDA ANTAGONISTS | MERRELL PHARMA INC (US) | 1996-03-20 | — | — | EP | disclosed |
| WO-1994027964-A1 | 3-(INDOL-3-YL) PROPENOIC ACID DERIVATIVES AND AS NMDA ANTAGONISTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-12-08 | — | — | WO | disclosed |
| EP-0543491-A2 | Angiotensin II antagonists having a substituted 1,3-benzodioxolering or 1,3-benzodithiolering | MERCK & CO. INC. (US) | 1993-05-26 | — | — | EP | disclosed |
| US-5187159-A | Hypotensive agents, psychological disorders | MERCK & CO., INC. (US) | 1993-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240228498-A1 | TERTIARY ALCOHOLS AS PI3K-y INHIBITORS | PIK3R5, PIK3R1, PIK3CD | CES2 2271/4885CES1 660/4885ALDH1A1 333/4885 |
| US-11339174-B2 | γ-spiroketal-γ-lactones and pharmaceutical composition containing same and process for preparation thereof | HSD17B7, PKD1, CYP17A1 | CES2 3614/4885CES1 895/4885ALDH1A1 420/4885 |
| US-20210198273-A1 | GAMMA-SPIROKETAL-GAMMA-LACTONES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AND PROCESS FOR PREPARATION THEREOF | HSD17B7, PKD1, CYP17A1 | CES2 3608/4885CES1 883/4885ALDH1A1 377/4885 |
| US-20260070874-A1 | BENZOYLFORMIC ACID AMIDE DERIVATIVE | CRYAA, BCAT1, BRCA1 | CES2 1111/4885CES1 945/4885ALDH1A1 88/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.