Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21246341 | 0.90 | LMNA (0.48) | CYP3A4POLBLMNAMEN1KMT2A | |
| SCHEMBL21246364 | 0.89 | CYP3A4 (0.41) | CYP3A4LMNATP53KDM4E | |
| SCHEMBL21246339 | 0.86 | PTPN1 (0.40) | LMNA | |
| SCHEMBL21246338 | 0.85 | KMT2A (0.38) | LMNATP53MEN1KMT2AKDM4E | |
| SCHEMBL21246428 | 0.85 | LMNA (0.48) | LMNATP53MEN1KMT2AALDH1A1 | |
| SCHEMBL21246368 | 0.84 | MAPT (0.44) | POLBLMNATP53ALDH1A1NAMPT | |
| SCHEMBL21246363 | 0.83 | HTT (0.46) | LMNAMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL21246366 | 0.83 | THRB (0.47) | CYP3A4POLBLMNAMEN1KMT2A | |
| SCHEMBL21246365 | 0.83 | TSHR (0.46) | CYP3A4POLBMEN1KMT2AALDH1A1 | |
| SCHEMBL21246427 | 0.82 | SLC1A2 (0.47) | CYP3A4LMNAKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019152688-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | APTINYX INC. (US) | 2019-08-08 | — | — | WO | disclosed |